Abstract:
:Kadsurenone, a specific receptor antagonist of platelet-activating factor (PAF), and its analogues were prepared from derivatives of cinnamyl alcohol and (allyloxy)phenol. Racemic kadsurenone, resolvable by a Chiralpak column at low temperatures, has an IC50 value of 2 X 10(-7) M, which is about 50% of the activity of the natural product (IC50 = 1 X 10(-7) M). The structural specificity of kadsurenone was further demonstrated by the low PAF-receptor-blocking activities of denudatin B, mirandin A, desallylkadsurenone, and the 2-epimer of kadsurenone.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Ponpipom MM,Bugianesi RL,Brooker DR,Yue BZ,Hwang SB,Shen TYdoi
10.1021/jm00384a023subject
Has Abstractpub_date
1987-01-01 00:00:00pages
136-42issue
1eissn
0022-2623issn
1520-4804journal_volume
30pub_type
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