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Correlation of psychotomimetic activity of phenethylamines and amphetamines with 1-octanol-water partition coefficients.

Abstract：

:In an attempt to relate the hallucinogenic potencies in man of some biologically important amphetamines and phenethylamines, the 1-octanol-water partition coefficients for 11 amphetamines were determined. Using these values and published Hansch pi constants, the log P for 17 additional amines was estimated. It was found that lipophilicity, as measured by the log of the partition coefficient, may be a significant determinant of the level of hallucinogenic potency. The study also suggests that an ideal log P value for psychotomimetric activity in man may be from 2.89 to 3.72.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Barfknecht CF,Nichols DE

doi

10.1021/jm00236a023

keywords:

subject

Has Abstract

pub_date

1975-02-01 00:00:00

pages

208-10

issue

2

eissn

0022-2623

issn

1520-4804

journal_volume

18

pub_type

杂志文章

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