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Energy aspects of oil/water partition leading to the novel hydrophobic parameters for the analysis of quantitative structure-activity relationships.

Abstract：

:Partition properties, that is partition coefficients and enthalpies (delta Hp degree) and entropies (delta Sp degree) of partition, have been measured for 50 benzoic acids in the 1-octanol/water system, and their role in QSAR (quantitative structure-activity relationship) analysis examined. The novel hydrophobic parameters have been introduced as a result of the separation of the Gibbs free energy term into the corresponding enthalpy and entropy terms. Application of these novel parameters to some available biological activity data supported the usefulness of these parameters in QSAR analysis. Relative contributions of the enthalpy and entropy terms are also discussed.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Da YZ,Ito K,Fujiwara H

doi

10.1021/jm00096a014

keywords:

subject

Has Abstract

pub_date

1992-09-04 00:00:00

pages

3382-7

issue

18

eissn

0022-2623

issn

1520-4804

journal_volume

35

pub_type

杂志文章

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