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Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.

Abstract：

:Resistance to chemotherapy and endocrine therapy is a major cause of breast cancer treatment failure. We have synthesized six novel analogues using C8-ceramide as the lead analogue and studied their effect on hormone therapy resistant (MDA-MB-231) and chemoresistant (MCF-7TN-R) breast cancer cells. Pharmacologic intervention using these ceramide analogues inhibited clonogenic survival and induced apoptosis, with one analogue being more effective than C8-ceramide. Our results show ceramide-based therapy has therapeutic potential in treating drug resistant breast cancer.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Antoon JW,Liu J,Gestaut MM,Burow ME,Beckman BS,Foroozesh M

doi

10.1021/jm9009668

subject

Has Abstract

pub_date

2009-09-24 00:00:00

pages

5748-52

issue

18

eissn

0022-2623

issn

1520-4804

journal_volume

52

pub_type

杂志文章

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