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Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis.

Abstract：

:The inhibition of chicken liver dihydrofolate reductase by a series of substituted benzylpyrimidines has been investigated. From the inhibition constants a quantitative structure-activity relationship has been formulated. This mathematical model is compared with molecular graphics models constructed from the X-ray crystallographic coordinates of trimethoprim and 5-(3,4-dimethoxy-4-isopropenylbenzyl)-2,4- diaminopyrimidine bound to the enzyme. There is good correspondence between the two types of models.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Selassie CD,Fang ZX,Li RL,Hansch C,Klein T,Langridge R,Kaufman BT

doi

10.1021/jm00155a006

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

621-6

issue

5

eissn

0022-2623

issn

1520-4804

journal_volume

29

pub_type

杂志文章

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