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5'-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor.

Abstract：

:The sodium ion site is an allosteric site conserved among many G protein-coupled receptors (GPCRs). Amiloride 1 and 5-(N,N-hexamethylene)amiloride 2 (HMA) supposedly bind in this sodium ion site and can influence orthosteric ligand binding. The availability of a high-resolution X-ray crystal structure of the human adenosine A2A receptor (hA2AAR), in which the allosteric sodium ion site was elucidated, makes it an appropriate model receptor for investigating the allosteric site. In this study, we report the synthesis and evaluation of novel 5'-substituted amiloride derivatives as hA2AAR allosteric antagonists. The potency of the amiloride derivatives was assessed by their ability to displace orthosteric radioligand [(3)H]4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]-[1,3,5]triazin-5-yl)amino)ethyl)phenol ([(3)H]ZM-241,385) from both the wild-type and sodium ion site W246A mutant hA2AAR. 4-Ethoxyphenethyl-substituted amiloride 12l was found to be more potent than both amiloride and HMA, and the shift in potency between the wild-type and mutated receptor confirmed its likely binding to the sodium ion site.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Massink A,Louvel J,Adlere I,van Veen C,Huisman BJ,Dijksteel GS,Guo D,Lenselink EB,Buckley BJ,Matthews H,Ranson M,Kelso M,IJzerman AP

doi

10.1021/acs.jmedchem.6b00142

subject

Has Abstract

pub_date

2016-05-26 00:00:00

pages

4769-77

issue

10

eissn

0022-2623

issn

1520-4804

journal_volume

59

pub_type

杂志文章

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