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Hemoglobin S antigelation agents based on 5-bromotryptophan with potential for sickle cell anemia.

Abstract：

:5-Bromotryptophan (5-BrTrp) is the most potent amino acid derivative reported in the literature to inhibit the gelation of hemoglobin S (from sickle cell anemia patients). Trp-Trp is also more potent than Trp as an antigelation agent. Therefore, we have prepared a series of dipeptides containing 5-BrTrp and evaluated the antigelation activity. 5-BrTrp-5-BrTrp is the most potent, i.e., 5.9 times the activity of Trp, followed by 5-BrTrp-Trp and then Trp-5-BrTrp. This improved antigelation potency for 5-BrTrp-5-BrTrp and 5-BrTrp-Trp is very significant and will be pursued further as lead compounds with potential for sickle cell anemia.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

De Croos PZ,Sangdee P,Stockwell BL,Kar L,Thompson EB,Johnson ME,Currie BL

doi

10.1021/jm00174a008

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

3138-42

issue

12

eissn

0022-2623

issn

1520-4804

journal_volume

33

pub_type

杂志文章

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