当前位置： SCI文献检索 > JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.

Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.

Abstract：

:Pyrazolo[3,4-d]pyrimidines are potent protein kinase inhibitors with promising antitumor activity but suboptimal aqueous solubility, consequently worth being further optimized. Herein, we present the one-pot two-step procedure for the synthesis of a set of pyrazolo[3,4-d]pyrimidine prodrugs (1a-8a and 9a-e) with higher aqueous solubility and enhanced pharmacokinetic and therapeutic properties. ADME studies demonstrated for the most promising prodrugs a better aqueous solubility, a favorable hydrolysis in human and murine serum, and an increased ability to cross cell membranes with respect to the parental drugs, explaining their better 24 h in vitro cytotoxicity against human glioblastoma U87 cell line. Finally, the 4-4a couple of drug/prodrug was also evaluated in vivo, revealing a profitable pharmacokinetic profile of the prodrug associated with a good efficacy. The application of the prodrug approach demonstrated to be a successful strategy for improving aqueous solubility of the parental drugs, determining a positive impact also in their biological efficacy.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Vignaroli G,Iovenitti G,Zamperini C,Coniglio F,Calandro P,Molinari A,Fallacara AL,Sartucci A,Calgani A,Colecchia D,Mancini A,Festuccia C,Dreassi E,Valoti M,Musumeci F,Chiariello M,Angelucci A,Botta M,Schenone S

doi

10.1021/acs.jmedchem.7b00637

subject

Has Abstract

pub_date

2017-07-27 00:00:00

pages

6305-6320

issue

14

eissn

0022-2623

issn

1520-4804

journal_volume

60

pub_type

杂志文章

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