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Bispyridinium cyclophanes: novel templates for human choline kinase inhibitors.

Abstract：

:The synthesis and biological activities of four novel bispyridinium cyclophanes as choline kinase (ChoK) inhibitors are presented. Their synthetic methodology has been optimized according to dilution, temperature, and reaction time and provides pure bispyridinium cyclophanes in high yields very easily. One of these cyclophanes (6, 4,8-diaza-3(1,4),9(4,1)-dipyridina-1(1,4),6(1,3)-dibenzenacyclodecaphan-3(1),9(1)-bis(ilium) dibromide) has an IC(50(ChoK)) of 0.3 microM and is the most potent human ChoK inhibitor described to date.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Conejo-García A,Campos JM,Sánchez-Martín RM,Gallo MA,Espinosa A

doi

10.1021/jm030792i

keywords:

subject

Has Abstract

pub_date

2003-08-14 00:00:00

pages

3754-7

issue

17

eissn

0022-2623

issn

1520-4804

journal_volume

46

pub_type

杂志文章

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