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Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.

Abstract：

:A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines with dopaminergic activity is described. The structure-activity relationships of this series were studied by synthesis of analogs and evaluation of their affinities for the dopamine (DA) D2 receptor and inhibition of locomotor activity (LMA) in rodents. The basic amine, alkyne chain length, and aryl groups were varied. Compounds having a 4-phenyl-1,2,3,6-tetrahydropyridine and an aryl group with hydrogen-bonding substituents separated by a butynyl chain were found to have the most potent dopaminergic activity. Several compounds that were found to have exceptional in vivo activity in LMA inhibition in rodents were evaluated for additional pharmacological activity including binding affinities for other DA receptor subtypes as well as effects on brain DA synthesis, DA neuronal firing, and conditioned avoidance responding in squirrel monkeys.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Glase SA,Akunne HC,Heffner TG,Jaen JC,MacKenzie RG,Meltzer LT,Pugsley TA,Smith SJ,Wise LD

doi

10.1021/jm950721m

subject

Has Abstract

pub_date

1996-08-02 00:00:00

pages

3179-87

issue

16

eissn

0022-2623

issn

1520-4804

pii

jm950721m

journal_volume

39

pub_type

杂志文章

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