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Synthesis and biological activity of potential antimetabolites of L-fucose.

Abstract：

:6-Substituted 6-deoxy-L-galactose (L-fucose) derivatives were synthesized as potential antimetabolites of L-fucose. The cytotoxic effects of these compounds were evaluated on P388 leukemia cells in culture. The L-fucose analogues which showed the most potent growth inhibition were the sulfonyl ester, bromo, and iodo derivatives; since these compounds were all capable of alkylation, it is conceivable that their cytotoxic action is a consequence of this property. In agreement with this interpretation, none of the agents synthesized showed specific inhibition of the incorporation of L-[3H]fucose into glycoprotein.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

May JA Jr,Sartorelli AC

doi

10.1021/jm00194a017

subject

Has Abstract

pub_date

1979-08-01 00:00:00

pages

971-6

issue

8

eissn

0022-2623

issn

1520-4804

journal_volume

22

pub_type

杂志文章

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