当前位置： SCI文献检索 > JOURNAL OF MEDICINAL CHEMISTRY期刊下所有文献 > Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.

Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.

Abstract：

:The protein kinase MKK7 is linked to neuronal development and the onset of cancer. The field, however, lacks high-quality functional probes that would allow for the dissection of its detailed functions. Against this background, we describe an effective covalent inhibitor of MKK7 based on the pyrazolopyrimidine scaffold.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Wolle P,Hardick J,Cronin SJF,Engel J,Baumann M,Lategahn J,Penninger JM,Rauh D

doi

10.1021/acs.jmedchem.9b00102

subject

Has Abstract

pub_date

2019-03-14 00:00:00

pages

2843-2848

issue

5

eissn

0022-2623

issn

1520-4804

journal_volume

62

pub_type

杂志文章

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