Abstract：
:AFTIR (after flowing through immobilized receptor) is a novel method for screening herbal extracts for pharmaceutical properties. Using AFTIR, we identified Cynarin in Echinacea purpurea by its selective binding to chip immobilized CD28, a receptor of T-cells, which is instrumental to immune functioning. The results of surface plasma resonance show that binding between immobilized CD28 and Cynarin is stronger than the binding between CD28 and CD80, a co-stimulated receptor of antigen presenting cells. Cynarin's function was verified by its ability to downregulate CD28-dependent interleukin-2 (IL-2) expression in a T-cell culture line. AFTIR offers promise as an efficient screening method for herbal medicines.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Dong GC,Chuang PH,Forrest MD,Lin YC,Chen HMdoi
10.1021/jm0509039keywords:
subject
Has Abstractpub_date
2006-03-23 00:00:00pages
1845-54issue
6eissn
0022-2623issn
1520-4804journal_volume
49pub_type
杂志文章abstract：:The effect of aromatic nitro compounds on the oxidative metabolism of representative type I (hexobarbital and aminopyrene) and type II (aniline and zoxazolamine) substrates by cytochrome P-450 dependent liver enzymes was studied. Nitro compounds (nitrobenzene, p-nitrobenzoate, 2-nitrofluorene, and 2-nitronaphthalene) ...
journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
doi：10.1021/jm00223a034
更新日期：1976-01-01 00:00:00
abstract：:Irreversible EGFR inhibitors can circumvent acquired resistance to first-generation reversible, ATP-competitive inhibitors in the treatment of non-small-cell lung cancer. They contain both a driver group, which assures target recognition, and a warhead, generally an acrylamide or propargylamide fragment that binds cov...
journal_title：Journal of medicinal chemistry
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更新日期：2010-03-11 00:00:00
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
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更新日期：2007-10-04 00:00:00
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pub_type： 杂志文章
doi：10.1021/jm00350a024
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journal_title：Journal of medicinal chemistry
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更新日期：2006-01-12 00:00:00
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journal_title：Journal of medicinal chemistry
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doi：10.1021/jm00125a020
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
doi：10.1021/jm00098a014
更新日期：1992-10-02 00:00:00
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
doi：10.1021/jm00158a038
更新日期：1986-08-01 00:00:00
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
doi：10.1021/jm9703348
更新日期：1997-07-04 00:00:00
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journal_title：Journal of medicinal chemistry
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doi：10.1021/jm00087a002
更新日期：1992-05-01 00:00:00
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
doi：10.1021/jm960726z
更新日期：1997-05-23 00:00:00
abstract：:N-Myristoyltransferase (NMT) is an attractive antiprotozoan drug target. A lead-hopping approach was utilized in the design and synthesis of novel benzo[b]thiophene-containing inhibitors of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) NMT. These inhibitors are selective against Homo sapiens NMT1 (HsNMT), have ...
journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
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journal_title：Journal of medicinal chemistry
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doi：10.1021/jm4000984
更新日期：2013-04-11 00:00:00
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journal_title：Journal of medicinal chemistry
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
doi：10.1021/acs.jmedchem.5b01511
更新日期：2016-02-25 00:00:00
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更新日期：2014-05-22 00:00:00
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
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更新日期：1998-12-03 00:00:00
abstract：:Mycobacterium abscessus (Mab) is a rapidly growing species of multidrug-resistant nontuberculous mycobacteria that has emerged as a growing threat to individuals with cystic fibrosis and other pre-existing chronic lung diseases. Mab pulmonary infections are difficult, or sometimes impossible, to treat and result in ac...
journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
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更新日期：2019-08-08 00:00:00
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journal_title：Journal of medicinal chemistry
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更新日期：2011-12-22 00:00:00
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journal_title：Journal of medicinal chemistry
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journal_title：Journal of medicinal chemistry
pub_type： 杂志文章
doi：10.1021/jm00023a012
更新日期：1995-11-10 00:00:00
