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Synthesis and biological activity of 8-arylergolines.

Abstract：

:9,10-Didehydro-6-methyl-8beta-arylergolines 2, in which the carboxyl group of lysergic acid and isolysergic acid is replaced by various aryl groups, were prepared in two steps by alkylation of aromatic substrates with the tetracyclic allylic alcohol 3, followed by aromatization with MnO2. The new ergolines 2 have modest prolactin-inhibiting and rat antimuricidal activities and possess significant alpha-blocking and antiserotonin properties.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Bach NJ,Kornfeld EC,Dorman DE

doi

10.1021/jm00218a025

subject

Has Abstract

pub_date

1977-08-01 00:00:00

pages

1105-7

issue

8

eissn

0022-2623

issn

1520-4804

journal_volume

20

pub_type

杂志文章

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