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Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.

Abstract：

:The structure of fenoterol, a beta2-adrenoceptor agonist used in therapy, has been joined with furoxan NO-donor moieties to give new NO-donor beta2-agonists. The furazan analogues, devoid of the property to release NO, were also synthesized for comparison. All the compounds retained beta2-agonistic activity at micromolar or submicromolar concentration when tested on guinea pig tracheal rings precontracted with carbachol. Among the furoxan derivatives, the NO contribution to trachea relaxation was evident with product 15b at micromolar concentrations. All the new NO-donor hybrids were able to dilate rat aortic strips precontracted with phenylephrine. Both furoxan and furazan derivatives displayed antioxidant activity greater than that of fenoterol.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Buonsanti MF,Bertinaria M,Stilo AD,Cena C,Fruttero R,Gasco A

doi

10.1021/jm0704595

subject

Has Abstract

pub_date

2007-10-04 00:00:00

pages

5003-11

issue

20

eissn

0022-2623

issn

1520-4804

journal_volume

50

pub_type

杂志文章

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