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Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 1. Substituted benzenedisulfonamides.

Abstract：

:A series of substituted benzenedisulfonamide carbonic anhydrase inhibitors is described and their anticonvulsant activities are listed. One compound, 4-(4-methoxypiperidinosulfonyl)-2-chlorobenzenesulfonamide (19, UK-12130), was found to have anticonvulsant activity in animals at a dose level that gave only a minimal diuretic effect. 19 selectively increased cerebral blood flow in animals and man without producing an unacceptable level of metabolic acidosis.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Cross PE,Gadsby B

doi

10.1021/jm00207a001

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

845-50

issue

9

eissn

0022-2623

issn

1520-4804

journal_volume

21

pub_type

杂志文章

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