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Analgesic and tranquilizing activity of 5,8-disubstituted 2-aminomethyl-3,4-dihydronaphthalenes.

Abstract：

:Interesting analgesic activity approaching that of meperidine and codeine was observed in standard animal models for 8-chloro-3,4-dihydro-5-methoxy-2-pyrrolidinomethylnaphthalene (compound 7). This compound was orally effective and its analgesic activity was not reversed by the opiate antagonist, naloxone. A limited number of other 2-aminomethyl analogues displayed activity in neuroleptic screens.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Welch WM,Plattner JJ,Stratten WP,Harbert CA

doi

10.1021/jm00201a004

subject

Has Abstract

pub_date

1978-03-01 00:00:00

pages

257-63

issue

3

eissn

0022-2623

issn

1520-4804

journal_volume

21

pub_type

杂志文章

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