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N-substituted 3-acetyltetramic acid derivatives as antibacterial agents.

Abstract：

:In order to expand the structure-activity relationship of tetramic acid molecules with structural similarity to the antibiotic reutericyclin, 22 compounds were synthesized and tested against a panel of clinically relevant bacteria. Key structural changes on the tetramic acid core affected antibacterial activity. Various compounds in the N-alkyl 3-acetyltetramic acid series exhibited good activity against Gram-positive bacterial pathogens including Bacillus anthracis, Propionibacterium acnes, Enterococcus faecalis, and both Methicillin-sensitive and -resistant Staphylococcus aureus.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Yendapally R,Hurdle JG,Carson EI,Lee RB,Lee RE

doi

10.1021/jm701356q

subject

Has Abstract

pub_date

2008-03-13 00:00:00

pages

1487-91

issue

5

eissn

0022-2623

issn

1520-4804

journal_volume

51

pub_type

杂志文章

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