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Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.

Abstract：

:In an analogy to the potent catechol dopamine D1 agonists dihydrexidine (1) and dinapsoline (2), benzo rings were fused onto the structures of the dopamine D2-selective agonists quinelorane (3) and quinpirole (4). Each of the phenyl ring-substituted derivatives had significant affinity for D2 receptors, albeit somewhat lower than the two parent compounds, 3 and 4. Compounds with N-propyl and N-allyl substituents (5b, 5c, 6c, and 6d) had higher affinity for the D2 dopamine receptor than did their corresponding secondary amines (5a and 6a). Slightly different effects on affinity of an n-propyl and an n-allyl group in the new analogues of 3 and 4 suggest that different binding orientations may be invoked at the receptor.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Doll MK,Nichols DE,Kilts JD,Prioleau C,Lawler CP,Lewis MM,Mailman RB

doi

10.1021/jm9804533

keywords:

subject

Has Abstract

pub_date

1999-03-11 00:00:00

pages

935-40

issue

5

eissn

0022-2623

issn

1520-4804

pii

jm9804533

journal_volume

42

pub_type

杂志文章

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