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A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.

Abstract：

:The availability of peptide and non-peptide Ang II receptor antagonists has permitted the study of Ang II receptor heterogeneity. It is now widely recognized that there are at least two distinct Ang II receptor subtypes. AT1 receptors are selective in their recognition of agents such as losartan, DuP 532, L-158,809, SK&F108566, and similar non-peptides. To date, all of the well-known actions of Ang II in mammals are blocked by the AT1 selective antagonists such as losartan and are thus designated as being mediated by the AT1 receptor. Although there have been reports of functional activity mediated through AT2 sites, the pharmacological role for the AT2 receptor has not yet been elucidated. Herein, we report the chemistry and SAR on a novel series of 1,2,3,4-tetrahydrosioquinoline-3-carboxylic acids which have selective affinity for AT2 receptors. The most potent of which (19) has an IC50 of 30 nM for the AT2 receptor in the rat adrenal radioligand binding assay.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

VanAtten MK,Ensinger CL,Chiu AT,McCall DE,Nguyen TT,Wexler RR,Timmermans PB

doi

10.1021/jm00077a001

subject

Has Abstract

pub_date

1993-12-10 00:00:00

pages

3985-92

issue

25

eissn

0022-2623

issn

1520-4804

journal_volume

36

pub_type

杂志文章

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