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Synthesis and biological activity of new peptide segments of gastrin exhibiting gastrin antagonist property.

Abstract：

:A series of C-terminal peptide segments of gastrin, i.e., (tert-butyloxycarbonyl)-L-tryptophyl-L-methionyl-L-aspartic acid amide, (tert-butyloxycarbonyl)-glycyl-L-tryptophyl-L-methionyl-L-aspartic acid amide, (tert-butyloxy-carbonyl)-L-tyrosyl-glycyl-L-tryptophyl-L-methionyl-L-asp artic acid amide, and (benzyloxycarbonyl)-L-glutamyl-L-alanyl-L-tyrosyl-glycyl-L-tryptophyl-L -methionyl-L-aspartic acid amide were prepared and were shown to competitively inhibit the binding of labeled human gastrin to its receptors in an isolated gastric mucosal cell preparation and to antagonize the action of gastrin on gastric acid secretion (ED50 from 1.5 to 7 mg/kg) in vivo in the reperfused rat stomach, determined according to the method of Ghosh and Schild. From these studies, it could be concluded that the C-terminal phenylalanine residue, which is of primary importance for intrinsic biological gastrin-like activity, is not essential for binding to gastrin receptors.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Martinez J,Magous R,Lignon MF,Laur J,Castro B,Bali JP

doi

10.1021/jm00378a012

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

1597-601

issue

12

eissn

0022-2623

issn

1520-4804

journal_volume

27

pub_type

杂志文章

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