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Tumor inhibitory triazenes. 3. Dealkylation within an homologous series and its relation to antitumor activity.

Abstract：

:The in vivo antitumor activity and in vitro metabolic dealkylation have been measured for an homologous series of 3-alkyl-1-(4-carbamoylphenyl)-3-methyltriazenes and have been compared with their partition coefficients. This investigation has shown that the extent of oxidative metabolism in vitro and the antitumor activity in vivo of these compounds are dependent upon hydrophobicity. These findings provide confirmation for the relationship between metabolism and antitumor activity for aryldialkyltriazenes.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Wilman DE,Cox PJ,Goddard PM,Hart LI,Merai K,Newell DR

doi

10.1021/jm00373a011

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

870-4

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

27

pub_type

杂志文章

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