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Rational approach to discover multipotent anti-Alzheimer drugs.

Abstract：

:The coupling of two different pharmacophores, each endowed with different biological properties, afforded the hybrid compound lipocrine (7), whose biological profile was markedly improved relative to those of prototypes tacrine and lipoic acid. Lipocrine is the first compound that inhibits the catalytic activity of AChE and AChE-induced amyloid-beta aggregation and protects against reactive oxygen species. Thus, it emerged as a valuable pharmacological tool to investigate Alzheimer's disease and as a promising lead compound for new anti-Alzheimer drugs.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Rosini M,Andrisano V,Bartolini M,Bolognesi ML,Hrelia P,Minarini A,Tarozzi A,Melchiorre C

doi

10.1021/jm049112h

keywords:

subject

Has Abstract

pub_date

2005-01-27 00:00:00

pages

360-3

issue

2

eissn

0022-2623

issn

1520-4804

journal_volume

48

pub_type

杂志文章

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