Abstract:
:In this report, we describe the synthesis of a new series of small amphiphilic aromatic compounds that mimic the essential properties of cationic antimicrobial peptides using Suzuki-Miyaura coupling. The new design allowed the easy tuning of the conformational restriction, controlled by introduction of intramolecular hydrogen bonds, and the overall hydrophobicity by modifications to the central ring and the side chains. This approach allowed us to better understand the influence of these features on the antimicrobial activity and selectivity. We found that the overall hydrophobicity had a more significant impact on antimicrobial and hemolytic activity than the conformational stiffness. A novel compound was discovered which has MICs of 0.78 μg/mL against S. Aureus and 6.25 μg/mL against E. Coli, similar to the well-known antimicrobial peptide, MSI-78.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Thaker HD,Sgolastra F,Clements D,Scott RW,Tew GNdoi
10.1021/jm101410tsubject
Has Abstractpub_date
2011-04-14 00:00:00pages
2241-54issue
7eissn
0022-2623issn
1520-4804journal_volume
54pub_type
杂志文章abstract::The crystal structure of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) in ternary complex with the coenzyme NADP (+) and the potent inhibitor 3,5-dichlorosalicylic acid was determined at a resolution of 1.8 A. The inhibitor is held in place by a network of hydrogen bonding interactions with the active site resid...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm8003575
更新日期:2008-08-14 00:00:00
abstract::(-)-(2R,4R)-1-(2-Hydroxymethyl-1,3-dioxolan-4-yl)thymine (DOT) is the first thymidine kinase-activated nucleoside that is significantly active against all of the clinically significant NRTI-resistant HIV-1 mutants, including AZT (D67N/K70R/T215Y/K219Q), Tenofovir (K65R), and Lamivudine (M184V). To understand the molec...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm050060l
更新日期:2005-06-16 00:00:00
abstract::Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compound...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/acs.jmedchem.9b00193
更新日期:2019-05-23 00:00:00
abstract::Several new phospholipid-ara-C conjugates have been prepared and tested as prodrugs of the parent ara-C. The new derivative include ara-CMP-L-dipalmitin, ara-CDP-L-distearin, ara-CDP-L dimyristin, ara-CDP-L-diolein, and the radioactively labeled derivative ara-CDP-L-di[1-14C]palmitin. In addition, the unusually stable...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00353a010
更新日期:1982-11-01 00:00:00
abstract::Here, we report the synthesis of a designed multi-pharmacophore ligand derived from the linkage of a delta selective peptide antagonist (Dmt-Tic) and a mu/kappa morphinan agonist butorphan (MCL 101) through a two methylene spacer. The new compound MCL 450 maintains the same characteristics as those the two reference c...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm0605785
更新日期:2006-09-07 00:00:00
abstract::The N-arginyl derivative of methionine-enkephalin (fragment 60-65 of beta-lipotropin) has been shown to be equiactive with the parent pentapeptide, despite the fact that the tyrosine amino group in this compound has been neutralized by the formation of an amide linkage. A series of N-(amino acid) derivatives of (-)-5,...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00143a007
更新日期:1981-11-01 00:00:00
abstract::The synthesis of diversely substituted 3-isopropoxy-, 3-isopropylsulfanyl-, 3-isopropylsulfinyl-, and 3-isobutyl-4H-1,2,4-benzothiadiazine 1,1-dioxides is described. Their activity on pancreatic β-cells (inhibitory effect on the insulin releasing process) and on vascular and uterine smooth muscle tissues (myorelaxant ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm200100c
更新日期:2011-05-12 00:00:00
abstract::On the basis of a mu opioid receptor (MOR) homology model and the isosterism concept, three generations of 14-heteroaromatically substituted naltrexone derivatives were designed, synthesized, and evaluated as potential MOR-selective ligands. The first-generation ligands appeared to be MOR-selective, whereas the second...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm4012214
更新日期:2013-11-27 00:00:00
abstract::Multidrug resistance (MDR) in cancer is a phenomenon in which administration of a single chemotherapeutic agent causes cross-resistance of cancer cells to a variety of therapies even with different mechanisms of action. Development of MDR against standard therapies is a major challenge in the treatment of cancer. Prev...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm200764t
更新日期:2011-08-25 00:00:00
abstract::A novel and highly efficient flexible docking approach is presented where the conformations (internal degrees of freedom) and orientations (external degrees of freedom) of the ligands are successively considered. This hybrid method takes advantage of the synergistic effects of structure-based and ligand-based drug des...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm0311386
更新日期:2004-08-12 00:00:00
abstract::Several derivatives of erythro-beta-hydroxy-DL-aspartic acid (1) were prepared as a potential inhibitors of L-asparagine synthetase (ASase) from rat Novikoff hepatoma. Benzylation of 1 gave the dibenzyl ester 2 which upon coupling with carbobenzoxyglycine afforded the blocked dipeptide 3. Deblocking of 3 gave glycl-er...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00238a006
更新日期:1975-04-01 00:00:00
abstract::8-Methoxy-1-oxo-2,3-dihydro-1H-cyclopenta]a]naphthalene (4) was converted to the oxalyl derivative (7) by treatment with diethyl oxalate in the presence of sodium ethoxide. Compound 7 in the form of the sodium salt was alkylated with ethyl bromoacetate in DMF to 2-(carbethoxymethyl)-8-methoxy-1-oxo-2,3-dihydro-1H-cycl...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00179a008
更新日期:1980-05-01 00:00:00
abstract::A series of analogues of Pro-Leu-Gly-NH2 (PLG) in which the leucine residue has been replaced with the aliphatic amino acids L-isoleucine, L-2-aminohexanoic acid (Ahx), L-2-aminopentanoic acid, and L-2-aminobutanoic acid and the aromatic amino acids L-phenylalanine, L-phenylglycine, L- and D-2-amino-4-phenylbutanoic a...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00168a045
更新日期:1990-06-01 00:00:00
abstract::A number of 1,2-benzisoxazoles, substituted in the 3 position with 4-substituted phenyl groups and in the 5--7 positions with acetic and propionic acid residues, have been synthesized and tested in the rat carrageenan foot edema assay. Activity has been found in the 6- and 7-substituted acids. ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00198a026
更新日期:1979-12-01 00:00:00
abstract::A series of base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine, a carbocyclic nucleoside, were synthesized and evaluated as inhibitors of S-adenosyl-L-methionine-dependent methyltransferases, including catechol O-methyltransferase, phenylethanolamine N-methyltransferase, and histamine N-methyl...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00382a016
更新日期:1985-04-01 00:00:00
abstract::Cyclic and acyclic nitroaryl phosphoramide mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT. The more active acyclic 4-nitrobenzyl phosphoramide mustard (7) showed 167 500x selective cytotoxicity toward nitroreductase-expressing V79 cells with an IC(50) as low as 0.4 nM. This is ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm034133h
更新日期:2003-11-06 00:00:00
abstract::A series of O-alkylated analogs of 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO) were synthesized and characterized as ligands for muscarinic acetylcholine receptors (mAChRs). O-Methyl-THAO (4a), O-ethyl-THAO (4b), O-isopropyl-THAO (4c), and O-propargyl-THAO (4d) were shown to be potent inhibitors of the bi...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00012a019
更新日期:1995-06-09 00:00:00
abstract::For a fourth approach of quinoxaline N,N'-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti-T. cruzi activity. Derivatives possessing electron-withdrawing subst...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm2002469
更新日期:2011-05-26 00:00:00
abstract::A comprehensive herbal medicine information system for cancer (CHMIS-C) has been developed. The current version of the database integrates information on more than 200 anticancer herbal recipes that have been used for the treatment of different types of cancer in clinic, 900 individual ingredients, and 8500 small orga...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm049838d
更新日期:2005-03-10 00:00:00
abstract::Inhibitor of apoptosis proteins (IAPs) are promising anticancer targets, given their roles in the evasion of apoptosis. Several peptidomimetic IAP antagonists, with inherent selectivity for cellular IAP (cIAP) over X-linked IAP (XIAP), have been tested in the clinic. A fragment screening approach followed by structure...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/acs.jmedchem.8b00900
更新日期:2018-08-23 00:00:00
abstract::From the discovery of competitive hexapeptide inhibitors, potent and selective HCV NS3 protease macrocyclic inhibitors have been identified. Structure-activity relationship studies were performed focusing on optimizing the N-terminal carbamate and the aromatic substituent on the (4R)-hydroxyproline moiety. Inhibitors ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm0342414
更新日期:2004-03-25 00:00:00
abstract::NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream from multiple TNF receptor family members, including BAFF, which has been associated with B cell survival and maturation, dendritic cell activation, secondary lymphoid organ development, and bone metabolism. We report ...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/acs.jmedchem.8b00678
更新日期:2018-08-09 00:00:00
abstract::The broad biological effects of isoquinolines prompted us to use them as chelating, nonleaving ligands in cis-platinum(II) antitumor complexes. The synthesis of several 1-(2-aminophenyl)isoquinoline derivatives with different levels of hydrogenation and varying substitution of the phenyl ring is reported. These compou...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm980434t
更新日期:1999-09-09 00:00:00
abstract::The nature of the carbonyl and nitrogen substituents of hydroxamic acids has a major influence on the biological profile of these compounds. Hydroxamates with small groups such as methyl appended to the carbonyl and relatively large nitrogen substituents generally have longer duration in vivo, produce greater plasma c...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00118a016
更新日期:1988-10-01 00:00:00
abstract::The amide functional group plays a key role in the composition of biomolecules, including many clinically approved drugs. Bioisosterism is widely employed in the rational modification of lead compounds, being used to increase potency, enhance selectivity, improve pharmacokinetic properties, eliminate toxicity, and acq...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章,评审
doi:10.1021/acs.jmedchem.0c00530
更新日期:2020-11-12 00:00:00
abstract::In a previous study, we described affinity labeling of the lamb uterine estrogen receptor by 17 alpha-[(bromoacetoxy)alkyl/alkynyl]estradiols. However, the intrinsic receptor-alkylating activities of these compounds were probably very hampered by their poor hydrolytic stability in estrogen receptor-containing tissue e...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00013a011
更新日期:1995-06-23 00:00:00
abstract::Reaction of nitric oxide (NO) with L-proline in methanolic sodium methoxide yields a diazeniumdiolate product, C5H7N3O4Na2.CH3OH (PROLI/NO), that can be stabilized in basic solution but that dissociates to proline (1 mol) and NO (2 mol) with a half-life of only 1.8 s at pH 7.4 and 37 degrees C. This kinetic behavior h...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm960616s
更新日期:1996-10-25 00:00:00
abstract::Study of surface representations of the inhibitor-bound thrombin P-1 pocket revealed a lipophilic recess in this pocket which is not occupied by any known inhibitor. Solid-phase synthesis was used to generate benzylamides of D-diphenylAlaPro by aminolysis of Boc dipeptide Kaiser resin. The resulting amides inhibited t...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm9706933
更新日期:1998-03-26 00:00:00
abstract::Structure-based macrocyclization of a 6-carboxylic acid indole chemotype has yielded potent and selective finger-loop inhibitors of the hepatitis C virus (HCV) NS5B polymerase. Lead optimization in conjunction with in vivo evaluation in rats identified several compounds showing (i) nanomolar potency in HCV replicon ce...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm401396p
更新日期:2014-03-13 00:00:00
abstract::Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) and the C-terminal partial sequences down to the tripeptide were synthesized by a solid-phase method. These peptides were assayed for vasodilator, spasmogenic, and venoconstrictor properties using three preparations, viz. the hind limb blood flow of the dog...
journal_title:Journal of medicinal chemistry
pub_type: 杂志文章
doi:10.1021/jm00228a028
更新日期:1976-06-01 00:00:00