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Discovery of a beta-MSH-derived MC-4R selective agonist.

Abstract：

:A series of novel, disulfide-constrained human beta-melanocyte stimulating hormone (beta-MSH)-derived peptides were optimized for in vitro melanocortin-4 receptor (MC-4R) binding affinity, agonist efficacy, and selectivity. The most promising of these, analogue 18, was further studied in vivo using chronic rat food intake and body weight models.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Mayer JP,Hsiung HM,Flora DB,Edwards P,Smith DP,Zhang XY,Gadski RA,Heiman ML,Hertel JL,Emmerson PJ,Husain S,O'brien TP,Kahl SD,Smiley DL,Zhang L,Dimarchi RD,Yan LZ

doi

10.1021/jm0501432

keywords:

subject

Has Abstract

pub_date

2005-05-05 00:00:00

pages

3095-8

issue

9

eissn

0022-2623

issn

1520-4804

journal_volume

48

pub_type

杂志文章

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