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Peptides containing β-amino acid patterns: challenges and successes in medicinal chemistry.

Abstract：

:The construction of bioactive peptides using β-amino acid-containing sequence patterns is a very promising strategy to obtain analogues that exhibit properties of high interest for medicinal chemistry applications. β-Amino acids have been shown to modulate the conformation, dynamics, and proteolytic susceptibility of native peptides. They can be either combined with α-amino acids by following specific patterns, which results in backbone architectures with well-defined orientations of the side chain functional groups, or assembled in de novo-designed bioactive β- or α,β-peptidic sequences. Such peptides display various biological functions, including antimicrobial activity, inhibition of protein-protein interactions, agonism/antagonism of GPCR ligands, and anti-angiogenic activity.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Cabrele C,Martinek TA,Reiser O,Berlicki Ł

doi

10.1021/jm5010896

subject

Has Abstract

pub_date

2014-12-11 00:00:00

pages

9718-39

issue

23

eissn

0022-2623

issn

1520-4804

journal_volume

57

pub_type

杂志文章

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