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Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds.

Abstract：

:In the course of studies on tranquilizers, new non-benzodiazepine-like compounds were synthesized. These are 1-(3,4,5-trimethoxyphenoxy)-3-[4-(2-methoxyphenyl)piperazinyl]prop an-2-ol (INN: enciprazine) and derivatives thereof which were screened pharmacologically in order to evaluate their central nervous system activity. Compounds with marked antiaggressive and anxiolytic properties but without dependence potential could be detected. Enciprazine was selected for clinical investigations.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Engel J,Fleischhauer I,Jakovlev V,Kleemann A,Kutscher B,Nickel B,Rauer H,Werner U,Szelenyi I,Johanson CE

doi

10.1021/jm00173a012

subject

Has Abstract,Author List Incomplete

pub_date

1990-11-01 00:00:00

pages

2976-81

issue

11

eissn

0022-2623

issn

1520-4804

journal_volume

33

pub_type

杂志文章

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