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Synthesis of some new S-alkylated derivatives of 5-mercapto-2'-deoxyuridine as potential antiviral agents.

Abstract：

:A series of S-alkylated derivatives of 5-mercapto-2'-deoxyuridine have been prepared by alkylation of the preformed nucleoside. Two of these compounds, the S-propargyl and S-allyl derivatives, have shown significant antiviral activity against Herpes simplex type 1 in HeLa TK- cells but appear to be less effective in this assay system than some previously reported 5-substituted 2'-deoxyuridines.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Dinan FJ,Bardos TJ

doi

10.1021/jm00179a019

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

569-72

issue

5

eissn

0022-2623

issn

1520-4804

journal_volume

23

pub_type

杂志文章

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