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Nucleoside 5'-monophosphate analogues. Synthesis of 5'-sulfamino-5'-deoxynucleosides.

Abstract：

:The synthesis of two new nucleotide analogues is described. 5'-Sulfamino-5'-deoxyadenosine (1) was prepared by reaction of 5'-amino-5'-deoxyadenosine with (CH3)3N.203, and 5'-sulfamino-5'-deoxythymidine (2) was prepared from 5'-amino-5'-deoxythymidine by a similar reaction. The 5'-sulfamino nucleosides are shown to be quite stable to hydrolysis in acidic or basic aqueous solution Tests show that these compounds do not inhibit the growth of Escherichia coli or L1210 cells at concentrations less than 10(-4) M. At 10(-4) M compound 2 was found to give 70% inhibition of the replication of herpes simplex virus (type 1) with no effect on host cell growth (CV-1 monkey line).

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Mungall WS,Lemmen LJ,Lemmen KL,Dethmers JK,Norling LL

doi

10.1021/jm00205a024

subject

Has Abstract

pub_date

1978-07-01 00:00:00

pages

704-6

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

21

pub_type

杂志文章

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