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Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds.

Abstract：

:Human African trypanosomiasis is causing thousands of deaths every year in the rural areas of Africa. In this manuscript we describe the optimization of a family of phtalazinone derivatives. Phosphodiesterases have emerged as attractive molecular targets for a novel treatment for a variety of neglected parasitic diseases. Compound 1 resulted in being a potent TbrPDEB1 inhibitor with interesting activity against T. brucei in a phenotypic screen. Derivative 1 was studied in an acute in vivo mouse disease model but unfortunately showed no efficacy due to low metabolic stability. We report structural modifications to achieve compounds with an improved metabolic stability while maintaining high potency against TbrPDEB1 and T. brucei. Compound 14 presented a good microsomal stability in mouse and human microsomes and provides a good starting point for future efforts.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Salado IG,Singh AK,Moreno-Cinos C,Sakaine G,Siderius M,Van der Veken P,Matheeussen A,van der Meer T,Sadek P,Gul S,Maes L,Sterk GJ,Leurs R,Brown D,Augustyns K

doi

10.1021/acs.jmedchem.9b00985

subject

Has Abstract

pub_date

2020-04-09 00:00:00

pages

3485-3507

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

63

pub_type

杂志文章

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