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Basic derivatives of 6,7-dihydroindolo(1,7-ab)(1) benzazepine and 6H-indolo(7,1-cd)(1,5) benzoxazepine as potential antidepressant agents.

Abstract：

:Basic derivatives of 6,7-dihydroindolo[1,7-ab][1]benzazepine and 6H-indolo[7,1-cd][1,5]benzoxazepine incorporating the imipramine basic side chain were synthesized and screened for antidepressant activity in mice. With few exceptions, the compounds unsubstituted at C-2 antagonized reserpine-induced ptosis and hypothermia showing negligible anticholinergic and antihistaminic properties. The compound 1-[2-(N-methyl-N-benzylamino)ethyl]-6,7-dihydroindolo[1,7-ab][1]benzazepine had the highest toxicity-activity ratio.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Toscano L,Grisanti G,Fioriello G,Seghetti E,Bianchetti A,Bossoni G,Riva M

doi

10.1021/jm00224a003

keywords:

subject

Has Abstract

pub_date

1976-02-01 00:00:00

pages

208-13

issue

2

eissn

0022-2623

issn

1520-4804

journal_volume

19

pub_type

杂志文章

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