Abstract:
:A series of 7-(3-amino- or 3-aminomethyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-o xo-3-quinolinecarboxylic acids was synthesized and tested for antibacterial activity. Unique to these quinolones was the presence of a methyl or phenyl group in the pyrrolidine ring. Although the in vitro activity of these agents was usually equal to or less than that of their unsubstituted counterparts, one quinolone, 7-[3-(aminomethyl)-3-methyl-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1 ,4-dihydro-4-oxo-3-quinolinecarboxylic acid, displayed exceptional potency both in vitro and in vivo, particularly against Gram-positive organisms.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Hagen SE,Domagala JM,Heifetz CL,Sanchez JP,Solomon Mdoi
10.1021/jm00164a060subject
Has Abstractpub_date
1990-02-01 00:00:00pages
849-54issue
2eissn
0022-2623issn
1520-4804journal_volume
33pub_type
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