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5-Oxo-ETE receptor antagonists.

Abstract：

:5-Oxo-ETE is the most powerful eosinophil chemoattractant among lipid mediators. Eosinophil infiltration into the lungs of asthmatics may be responsible for the late phase of inflammatory asthma. We have designed and synthesized a 5-oxo-ETE receptor antagonist, the purpose of which is to prevent eosinophil migration to the lung during an asthma attack and thereby reduce asthma symptoms.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Gore V,Patel P,Chang CT,Sivendran S,Kang N,Ouedraogo YP,Gravel S,Powell WS,Rokach J

doi

10.1021/jm400480j

subject

Has Abstract

pub_date

2013-05-09 00:00:00

pages

3725-32

issue

9

eissn

0022-2623

issn

1520-4804

journal_volume

56

pub_type

杂志文章

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