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Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition.

Abstract：

:The N332 high-mannose glycan on the HIV-1 gp120 V3-loop is the target of many bNAbs. About 17% HIV isolates carry the N332 to N334 mutation, but the antibody recognition of the N334 N-glycan and its immunogenicity are not well characterized. Here we report the chemoenzymatic synthesis, antigenicity, and immunogenicity of the V3 N334 glycopeptides from HIV-1 A244 gp120, a key component in the partially successful Thai clinical trials. We found that synthetic V3 glycopeptide carrying a N334 high-mannose glycan could be recognized by bNAb PGT128 and PGT126 but not by 10-1074. Rabbit immunization with the synthetic three-component A244 glycopeptide immunogen elicited substantial glycan-dependent antibodies with broad reactivity to various HIV-1 gp120/gp140 carrying N332 or N334 glycosylation sites. These results indicated that the N334 site is vulnerable and the A244 V3 glycopeptide represents a valuable immunogen for further HIV-1 vaccine studies.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Cai H,Zhang RS,Orwenyo J,Giddens J,Yang Q,LaBranche CC,Montefiori DC,Wang LX

doi

10.1021/acs.jmedchem.8b01290

subject

Has Abstract

pub_date

2018-11-21 00:00:00

pages

10116-10125

issue

22

eissn

0022-2623

issn

1520-4804

journal_volume

61

pub_type

杂志文章

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