beta-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols.

Abstract:

:The synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. The compounds were investigated for their beta-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized cats for their effects on an isoproterenol-induced tachycardia and depressor response. The structure-activity relationship shown by this series of compounds is related to that of known cardioselective analogues and a possible reason for their cardioselectivity is discussed.

journal_name

J Med Chem

authors

Smith LH,Tucker H

doi

10.1021/jm00222a022

subject

Has Abstract

pub_date

1977-12-01 00:00:00

pages

1653-6

issue

12

eissn

0022-2623

issn

1520-4804

journal_volume

20

pub_type

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