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Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons.

Abstract：

:A series of D-erythro- and L-threo-ceramide analogues was synthesized and investigated for their ability to reverse the inhibitory effects of fumonisin B(1) (FB(1)) on axonal growth in hippocampal neurons. The analogues contained either a C(7) side chain or a phenyl group substituted for the C(13) residue present in naturally occurring ceramides, while the N-acyl chain length was reduced from C(16)-C(24) to C(2)-C(8). D-erythro-Ceramide 18a with a C(7) side chain and an N-acetyl residue and D-erythro-ceramide 20c with an aromatic side chain and an N-hexanoyl residue were most active in reversing the inhibitory effects of FB(1) on axonal growth, although the mechanism remains unclear.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Van Overmeire I,Boldin SA,Dumont F,Van Calenbergh S,Slegers G,De Keukeleire D,Futerman AH,Herdewijn P

doi

10.1021/jm990091e

keywords:

subject

Has Abstract

pub_date

1999-07-15 00:00:00

pages

2697-705

issue

14

eissn

0022-2623

issn

1520-4804

pii

jm990091e

journal_volume

42

pub_type

杂志文章

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