Concentration and in vivo synthesis of cholecystokinin in subcortical regions of the rat brain.

abstract：:Corticotropin-releasing factor (CRF) stimulates rat retinal adenylate cyclase activity in a concentration-dependent manner. The half-maximal effect is obtained at 50 nM CRF and the maximal stimulation corresponds to approximately 90% increase of basal enzyme activity. The CRF effect is counteracted by the CRF antagoni...

journal_title：Journal of neurochemistry

authors： Olianas MC,Onali P

更新日期：1990-06-01 00:00:00

abstract：:Exosomes are small extracellular vesicles released by almost all cell types in physiological and pathological conditions. The exosomal potential to unravel disease mechanisms, or to be used as a source of biomarkers, is being explored, in particularly in the field of neurodegenerative diseases. Alzheimer's disease (AD...

journal_title：Journal of neurochemistry

authors： Soares Martins T,Trindade D,Vaz M,Campelo I,Almeida M,Trigo G,da Cruz E Silva OAB,Henriques AG

更新日期：2020-07-03 00:00:00

abstract：:A dipeptidyl aminopeptidase was partially purified from a supernatant fraction of bovine adrenal medulla by gel filtration and anion-exchange chromatography. From gel filtration, the apparent molecular weight of the enzyme was 68,100 and its pH optimum was 9.5. Its Km for hydrolysis of the synthetic substrate arginyla...

journal_title：Journal of neurochemistry

authors： Kecorius E,Small DH,Livett BG

更新日期：1988-01-01 00:00:00

abstract：:Choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, I.U.B. 2.3.1.6) activity and total protein content in visual and extra-visual areas were compared in normal Long-Evans rats and in rats subjected to complete light-deprivation for 21 days from birth. The enzyme activity and the protein content in the ...

journal_title：Journal of neurochemistry

authors： Maletta GJ,Timiras PS

更新日期：1968-08-01 00:00:00

abstract：:The (R) and (S) forms of 5-amino-2-hydroxyvaleric acid (2-OH-DAVA) and 5-amino-4-hydroxyvaleric acid (4-OH-DAVA) were designed as structural hybrids of the 4-aminobutyric acidB (GABAB) agonist (R)-(-)-4-amino-3-hydroxybutyric acid [(R)-(-)-3-OH-GABA] and the GABAB antagonist 5-aminovaleric acid (DAVA). (S)-(-)-2-OH-DA...

journal_title：Journal of neurochemistry

authors： Kristiansen U,Hedegaard A,Herdeis C,Lund TM,Nielsen B,Hansen JJ,Falch E,Hjeds H,Krogsgaard-Larsen P

更新日期：1992-03-01 00:00:00

abstract：:We report that a subtoxic dose of the succinate dehydrogenase (SDH) inhibitor malonate greatly enhances the neurotoxicity of three different excitatory amino acid agonists: N-methyl-D-aspartate (NMDA), S-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (S-AMPA), and L-glutamate. In male Sprague-Dawley rats, in...

journal_title：Journal of neurochemistry

authors： Greene JG,Greenamyre JT

更新日期：1995-05-01 00:00:00

abstract：:Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) have been implicated in membrane-cytoskeletal events underlying cell adhesion, migration, secretion, and phagocytosis. In BV-2 microglial cells, lipopolysaccharide (LPS) elicited a dose-dependent increase in mRNA of both MRP (sixfo...

journal_title：Journal of neurochemistry

authors： Sunohara JR,Ridgway ND,Cook HW,Byers DM

更新日期：2001-08-01 00:00:00

abstract：:Epinephrine (Epi) mediates various physiological effects via alpha2A-adrenergic receptors (alpha2A-ARs). Studies in mice with a point mutation in the gene for alpha2A-AR have shown that these receptors are responsible for the centrally mediated depressor effects of alpha2-AR agonists. These studies underscore the impo...

journal_title：Journal of neurochemistry

authors： Reutter MA,Richards EM,Sumners C

更新日期：1998-01-01 00:00:00

abstract：:Certain non-steroidal anti-inflammatory drugs (NSAIDs) preferentially inhibit production of the amyloidogenic Abeta42 peptide, presumably by direct modulation of gamma-secretase activity. A recent report indicated that NSAIDs could reduce Abeta42 by inhibition of the small GTPase Rho, and a single inhibitor of Rho kin...

journal_title：Journal of neurochemistry

authors： Leuchtenberger S,Kummer MP,Kukar T,Czirr E,Teusch N,Sagi SA,Berdeaux R,Pietrzik CU,Ladd TB,Golde TE,Koo EH,Weggen S

更新日期：2006-01-01 00:00:00

abstract：:The autoradiographic method with L-[35S]methionine was used to determine the effects of an n-3 fatty acid deficiency on brain protein synthesis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-deficient rats as compared with control anima...

journal_title：Journal of neurochemistry

authors： Giaume M,Gay N,Baubet V,Gharib A,Durand G,Bobillier P,Sarda N

更新日期：1994-11-01 00:00:00

abstract：:Rats learning the Morris water maze exhibit hippocampal changes in synaptic morphology and physiology that manifest as altered synaptic efficacy. Learning requires structural changes in the synapse, and multiple cell adhesion molecules appear to participate. The activity of these cell adhesion molecules is, in large p...

journal_title：Journal of neurochemistry

authors： Meighan SE,Meighan PC,Choudhury P,Davis CJ,Olson ML,Zornes PA,Wright JW,Harding JW

更新日期：2006-03-01 00:00:00

abstract：:Microdialysis in the awake, freely moving rat was used to determine the effect of pyrithiamine-induced thiamine deficiency on the levels of amino acids in the brain. Studies were carried out on (a) presymptomatic animals immediately before the development of behavioral changes and (b) acute symptomatic animals within ...

journal_title：Journal of neurochemistry

authors： Hazell AS,Butterworth RF,Hakim AM

更新日期：1993-09-01 00:00:00

abstract：:In the early postnatal period, energy metabolism in the suckling rodent brain relies to a large extent on metabolic pathways alternate to glucose such as the utilization of ketone bodies (KBs). However, how KBs affect neuronal excitability is not known. Using recordings of single NMDA and GABA-activated channels in ne...

journal_title：Journal of neurochemistry

authors： Rheims S,Holmgren CD,Chazal G,Mulder J,Harkany T,Zilberter T,Zilberter Y

更新日期：2009-08-01 00:00:00

abstract：:Our previous observations have shown that neuroactive steroid levels in the brain are affected by acute experimental autoimmune encephalomyelitis (EAE) with sex and regional specificity (Giatti et al. 2010). To better understand the effect of EAE on neuroactive steroids, we have here assessed the levels of pregnenolon...

journal_title：Journal of neurochemistry

authors： Caruso D,D'Intino G,Giatti S,Maschi O,Pesaresi M,Calabrese D,Garcia-Segura LM,Calza L,Melcangi RC

更新日期：2010-08-01 00:00:00

abstract：:The human NMDAR2D subunit was cloned, and the pharmacological properties of receptors resulting from injection of transcripts encoding human NMDAR1A and NMDAR2D subunits in Xenopus oocytes were characterized by profiling NMDA receptor agonists and antagonists. We found that glutamate, NMDA, glycine, and D-serine were ...

journal_title：Journal of neurochemistry

authors： Hess SD,Daggett LP,Deal C,Lu CC,Johnson EC,Veliçelebi G

更新日期：1998-03-01 00:00:00

abstract：:The cause of neuronal degeneration in Alzheimer's disease (AD) has not been completely clarified, but has been variously attributed to increases in cytosolic calcium and increased generation of reactive oxygen species (ROS). The beta-amyloid fragment (Abeta) of the amyloid precursor protein induces calcium influx, ROS...

journal_title：Journal of neurochemistry

authors： Ho PI,Collins SC,Dhitavat S,Ortiz D,Ashline D,Rogers E,Shea TB

更新日期：2001-07-01 00:00:00

abstract：:Early malnutrition is a risk factor for depression and schizophrenia. Since the offspring of malnourished dams exhibit increased brain levels of serotonin (5-HT), a tryptophan-derived neurotransmitter involved in the pathophysiology of these mental disorders, it is believed that the deleterious effects of early malnut...

journal_title：Journal of neurochemistry

authors： Honório de Melo Martimiano P,de Sa Braga Oliveira A,Ferchaud-Roucher V,Croyal M,Aguesse A,Grit I,Ouguerram K,Lopes de Souza S,Kaeffer B,Bolaños-Jiménez F

更新日期：2017-01-01 00:00:00

abstract：:The possible modulation of nitric oxide (NO) synthase (NOS) activity by protein kinase C (PKC) was investigated. Incubation of rat cerebellar slices with the specific metabotropic glutamate receptor agonist, (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylate (trans-ACPD) increased cyclic GMP concentration two-fold. The...

journal_title：Journal of neurochemistry

authors： Okada D

更新日期：1995-03-01 00:00:00

abstract：:Disulfide-bridged S100b protein formation, aircatalyzed and induced by thiol/disulfide exchange, was studied under various ionic conditions. As native, physiological disulfide-bridged proteins are obtained easily from their reduced counterparts under appropriate redox conditions, this work was performed to determine w...

journal_title：Journal of neurochemistry

authors： Mely Y,Gérard D

更新日期：1990-10-01 00:00:00

abstract：:We have observed recently that in vitro lipoperoxidation is enhanced in Down's syndrome brain homogenates of prenatal age. As this may relate to the composition of polyunsaturated acyl groups (PUFA) in phospholipids, we have examined the PUFA of ethanolamine and serine phosphoglycerides (EPG and SPG), which are partic...

journal_title：Journal of neurochemistry

authors： Brooksbank BW,Martinez M,Balazs R

更新日期：1985-03-01 00:00:00

abstract：:Presynaptic receptors modulating the release of acetylcholine (ACh) were studied in fetal septal neurons cultured in a growth medium to which various drugs were added from day 3 in vitro (DIV 3) to DIV 14. The influence of these drugs on the function of the presynaptic muscarinic (M-) autoreceptor was determined at DI...

journal_title：Journal of neurochemistry

authors： Ehret A,Birthelmer A,Rutz S,Riegert C,Rothmaier AK,Jackisch R

更新日期：2007-08-01 00:00:00

abstract：:The myelin transcription factor 1 (Myt1) gene family is comprised of three zinc finger genes [Myt1, Myt1L (Myt1-Like) and NZF3] of the structurally unique CCHHC class that are expressed predominantly in the developing CNS. To understand the mechanism by which this family regulates neural differentiation, we searched f...

journal_title：Journal of neurochemistry

authors： Romm E,Nielsen JA,Kim JG,Hudson LD

更新日期：2005-06-01 00:00:00

abstract：:Primary dopaminergic neuronal cultures with increased superoxide dismutase (SOD) activity were established for studying the role of superoxide anion (O2-) in 1-methyl-4-phenylpyridinium (MPP+)-induced degeneration of dopamine (DA) neurons. Mean SOD activity in cultures prepared from transgenic (human) Cu/Zn SOD (hSOD1...

journal_title：Journal of neurochemistry

authors： Sanchez-Ramos JR,Song S,Facca A,Basit A,Epstein CJ

更新日期：1997-01-01 00:00:00

abstract：:The effects of fatty acids, oleate and palmitate, on gamma-aminobutyric acid (GABA), aspartate, and 3,4- dihydroxyphenylethylamine (dopamine) transport and a variety of other membrane functions were studied in rat brain synaptosomes at a constant lipid-to-protein ratio. Under the conditions utilized oleate, but not pa...

journal_title：Journal of neurochemistry

authors： Troeger MB,Rafalowska U,Erecińska M

更新日期：1984-06-01 00:00:00

abstract：:The choline acetyltransferase (ChAT) reaction involves the transfer of the acetyl group of acetyl-CoA to choline, in which an active site histidine is believed to act as a general acid/base catalyst. A comparison of the deduced amino acid sequences of the enzyme from Drosophila, pig, rat, and Caernohabditis elegans re...

journal_title：Journal of neurochemistry

authors： Carbini LA,Hersh LB

更新日期：1993-07-01 00:00:00

abstract：:GABA(A) receptors are the major inhibitory neurotransmitter receptors in the brain. Some of them are targets of benzodiazepines that are widely used in clinical practice for their sedative/hypnotic, anxiolytic, muscle relaxant and anticonvulsant effects. In order to rationally separate these different drug actions, we...

journal_title：Journal of neurochemistry

authors： Tan KR,Baur R,Charon S,Goeldner M,Sigel E

更新日期：2009-12-01 00:00:00

abstract：:Several cholinesterase inhibitors used in the treatment of Alzheimer's disease (AD) have been shown to interact with an allosteric site on the nicotinic acetylcholine receptor (nAChR). A possible linkage between the phosphorylation state of tau, the major component of paired helical filaments found in AD brain, and st...

journal_title：Journal of neurochemistry

authors： Hellström-Lindahl E,Moore H,Nordberg A

更新日期：2000-02-01 00:00:00

abstract：:A distinctive autofluorescence under ultraviolet light has been observed in the cerebral cortex of young ruminants suffering from cerebrocortical necrosis. The fluorescence is intimately connected with structural elements of the brain and cannot be extracted into solvents by normal procedures. The work presented here ...

journal_title：Journal of neurochemistry

authors： Edwin EE,Jackman R

更新日期：1981-10-01 00:00:00

abstract：:Uptake and release of alanine were measured in lumbar sympathetic chains excised from embryos of white leghorn chickens, 14-15 days old, and incubated in a modified Eagle's minimum essential medium. In the presence of [U-14C]glucose, glucose carbon accumulated in alanine in the medium at a rate that increased when unl...

journal_title：Journal of neurochemistry

authors： Larrabee MG

更新日期：1984-09-01 00:00:00

abstract：:Tissue plasminogen activator (tPA) is necessary for hippocampal long-term potentiation. Synaptically released zinc also contributes to long-term potentiation, especially in the hippocampal CA3 region. Using cortical cultures, we examined whether zinc increased the concentration and/or activity of tPA. Two hours after ...

journal_title：Journal of neurochemistry

authors： Hwang IY,Sun ES,An JH,Im H,Lee SH,Lee JY,Han PL,Koh JY,Kim YH

更新日期：2011-09-01 00:00:00