Nature of the autofluorescent material in cerebrocortical necrosis.

abstract：:This study focuses on the potential involvement of carnitine palmitoyltransferase (CPT) on the phospholipid and triglyceride fatty acid turnover in neurons. This category of enzymes, which has been identified in several rat brain tissues, is well known for its role in modulating cellular fatty acid oxidation. Neuronal...

journal_title：Journal of neurochemistry

authors： Arduini A,Denisova N,Virmani A,Avrova N,Federici G,Arrigoni-Martelli E

更新日期：1994-04-01 00:00:00

abstract：:The translocation of intravenously administered tritiated 3-O-methyl-D-glucopyranose (3-OMG) into brain has been studied in an intact nephrectomized rat preparation by infusing a series of hexoses into one internal carotid artery. 3-OMG rapidly penetrated into brain with peak concentrations, attained 5-8 min after inj...

journal_title：Journal of neurochemistry

authors： Bidder TG

更新日期：1968-08-01 00:00:00

abstract：:The normal cellular form of prion protein (PrP(C)) has been shown to exhibit a diverse range of biological activities. Several recent studies highlighted potential involvement of PrP(C) in embryogenesis or in regulating stem cell self-renewal and proliferation. In the current study, we employed human embryonic stem ce...

journal_title：Journal of neurochemistry

authors： Lee YJ,Baskakov IV

更新日期：2010-07-01 00:00:00

abstract：:Light stimulates dopamine release in the retina and has been shown to rapidly up-regulate rod opsin mRNA. In the present study, we tested the effect of dopamine on rod opsin mRNA expression and examined the hypothesis that dopamine can mediate a light-evoked increase in opsin gene expression. Northern blots showed tha...

journal_title：Journal of neurochemistry

authors： Alfinito PD,Townes-Anderson E

更新日期：2001-02-01 00:00:00

abstract：:Leptin, the obese gene product, was reported to stimulate prolactin (PRL) secretion, but the neuroendocrine mechanism underlying this hormonal response is largely unknown. Thus, in this study we examined the involvement of several important PRL regulators in the leptin-induced PRL secretion in male rats. Compared with...

journal_title：Journal of neurochemistry

authors： Watanobe H,Schiöth HB,Izumi J

更新日期：2003-04-01 00:00:00

abstract：:Neural progenitor cells isolated from the embryonic cerebral cortex are well known to differentiate into neurons and glial cells, but recent reports have demonstrated differentiation into smooth muscle cells (SMCs) under the influence of fetal bovine serum. In this study, we report that agonists for G protein-coupled ...

journal_title：Journal of neurochemistry

authors： Morishita R,Nagata K,Ito H,Ueda H,Asano M,Shinohara H,Kato K,Asano T

更新日期：2007-05-01 00:00:00

abstract：:The relationships between presynaptic acetylcholinesterase (AChE) and high-affinity choline uptake (HACU) were investigated using a monolayer of rat cortex synaptosomes in superfusion conditions. The following sets of experiments were performed: determination of [3H]choline ([3H]Ch) uptake during superfusion with [3H]...

journal_title：Journal of neurochemistry

authors： Raiteri M,Marchi M,Caviglia AM

更新日期：1986-12-01 00:00:00

abstract：:The developing central nervous system is a primary target of ethanol toxicity. The teratogenic effect of ethanol may result from its action on prostaglandins. Prostaglandins are generated through the release of arachidonic acid (AA) by the action of cytosolic phospholipase A(2) (cPLA(2)) on membrane-bound phospholipid...

journal_title：Journal of neurochemistry

authors： Luo J,Lindström CL,Donahue A,Miller MW

更新日期：2001-03-01 00:00:00

abstract：:The aggravating effect of hyperglycemia on ischemic brain injury can be mimicked in a model of in vitro ischemia (IVI) using murine hippocampal slice cultures. Using this model, we found that the damage in the CA1 region following IVI in the absence or presence of 40 mm glucose (hyperglycemia) is highly temperature de...

journal_title：Journal of neurochemistry

authors： Rytter A,Cardoso CM,Johansson P,Cronberg T,Hansson MJ,Mattiasson G,Elmér E,Wieloch T

更新日期：2005-11-01 00:00:00

abstract：:Tetanus and botulinum toxins bind and are internalized at the neuromuscular junction. Botulinum neurotoxins (BoNTs) enter the cytosol at the motor nerve terminal; tetanus neurotoxin (TeNT) proceeds retroaxonally inside the motor axon to reach the spinal cord inhibitory interneurons. Although the major target of BoNTs ...

journal_title：Journal of neurochemistry

authors： Verderio C,Coco S,Rossetto O,Montecucco C,Matteoli M

更新日期：1999-07-01 00:00:00

abstract：:In the present study, neuronal and Schwann cell marker proteins were used to biochemically characterize the spatiotemporal progress of degeneration/regeneration in the silicone chamber model for nerve regeneration. Rat sciatic nerves were transected and the proximal and distal stumps were inserted into a bridging sili...

journal_title：Journal of neurochemistry

authors： Karlsson JE,Rosengren LE,Wang S,Danielsen N,Haglid KG

更新日期：1993-03-01 00:00:00

abstract：:An alteration in signal transduction systems in Alzheimer's disease (AD) would likely be of pathophysiological significance, because these processes control normal brain functions. Previously, a diminished beta-adrenergic-mediated cyclic AMP response was found in cultured fibroblasts from AD patients. Because cross-ta...

journal_title：Journal of neurochemistry

authors： Huang HM,Lin TA,Sun GY,Gibson GE

更新日期：1995-02-01 00:00:00

abstract：:Androgens affect cognitive processes in both humans and animals. The effects of androgens may be limited to certain cognitive domains, specifically spatial memory, but this hypothesis remains elusive. Here, we tested castrated and sham-operated mice in various behavioral tasks to ask whether androgens affect multiple ...

journal_title：Journal of neurochemistry

authors： Benice TS,Raber J

更新日期：2009-08-01 00:00:00

abstract：:Several Good buffers (MOPS, ACES, BES, HEPES, ADA, and PIPES) competitively inhibited both high-affinity and low-affinity [3H]gamma-aminobutyric acid receptor binding to rat brain synaptic membranes. The most potent inhibitor was MOPS, which had Ki values of 180 nM and 79 nM for the high- and low-affinity binding site...

journal_title：Journal of neurochemistry

authors： Tunnicliff G,Smith JA

更新日期：1981-03-01 00:00:00

abstract：:Metabotropic glutamate receptor (type 1; mGluR1) is expressed predominantly in the hippocampus and the cerebellum. Using cultured cerebellar granule cells, we investigated the regulation of the mGluR1 mRNA expression. Levels of mGluR1 mRNA were decreased to less than half by high potassium stimulation and by glutamate...

journal_title：Journal of neurochemistry

authors： Bessho Y,Nawa H,Nakanishi S

更新日期：1993-01-01 00:00:00

abstract：:Leptin regulates energy balance by suppressing appetite and increasing energy expenditure through actions in the hypothalamus. Recently we demonstrated that the effects of leptin are, at least in part, mediated by the release of interleukin (IL)-1beta in the brain. Microglia constitute the major source of IL-1beta in ...

journal_title：Journal of neurochemistry

authors： Pinteaux E,Inoue W,Schmidt L,Molina-Holgado F,Rothwell NJ,Luheshi GN

更新日期：2007-08-01 00:00:00

abstract：:Protein synthesis in the brain is known to be affected by a wide range of treatments. The detailed analysis of the mechanisms that are involved would be facilitated by the development of cell-free translation systems derived from brain tissue. To date, brain cell-free systems have not been fully characterized to demon...

journal_title：Journal of neurochemistry

authors： Cosgrove JW,Brown IR

更新日期：1981-03-01 00:00:00

abstract：:Several lines of evidence implicate excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis (ALS). Transgenic mice with a superoxide dismutase mutation (G93A) have been utilized as an animal model of familial ALS (FALS). We examined the cortical concentrations of glutamate using in vivo microdialys...

journal_title：Journal of neurochemistry

authors： Andreassen OA,Jenkins BG,Dedeoglu A,Ferrante KL,Bogdanov MB,Kaddurah-Daouk R,Beal MF

更新日期：2001-04-01 00:00:00

abstract：:The olfactory bulb is one of the most vulnerable brain regions in age-related proteinopathies. Proteinopathic stress is mitigated by the heat shock protein (Hsp) family of chaperones. Here, we describe age-related decreases in Hsc70 in the olfactory bulb of the female rat and higher levels of Hsp70 and Hsp25 in middle...

journal_title：Journal of neurochemistry

authors： Crum TS,Gleixner AM,Posimo JM,Mason DM,Broeren MT,Heinemann SD,Wipf P,Brodsky JL,Leak RK

更新日期：2015-06-01 00:00:00

abstract：:In complex tissues where multiple subtypes of nicotinic acetylcholine receptors (nAChRs) are expressed, immunohistochemistry has been the most popular tool for investigation of nAChR subunit distribution. However, recent studies with nAChR subunit knockout mice demonstrated that a large panel of antibodies is unsuitab...

journal_title：Journal of neurochemistry

authors： Shelukhina IV,Kryukova EV,Lips KS,Tsetlin VI,Kummer W

更新日期：2009-05-01 00:00:00

abstract：:Phospholipase A2 (PLA2) is the name for the class of lipolytic enzymes that hydrolyze the acyl group from the sn-2 position of glycerophospholipids, generating free fatty acids and lysophospholipids. The products of the PLA2-catalyzed reaction can potentially act as second messengers themselves, or be further metaboli...

journal_title：Journal of neurochemistry

authors： Farooqui AA,Yang HC,Rosenberger TA,Horrocks LA

更新日期：1997-09-01 00:00:00

abstract：:The synaptosomal metabolism of glutamine was studied under in vitro conditions that simulate depolarization in vivo. With [2-15N]glutamine as precursor, the [glutamine]i was diminished in the presence of veratridine or 50 mM KCl, but the total amounts of [15N]glutamate and [15N]aspartate formed were either equal to th...

journal_title：Journal of neurochemistry

authors： Erecińska M,Zaleska MM,Nelson D,Nissim I,Yudkoff M

更新日期：1990-06-01 00:00:00

abstract：:Recombinant RGS1, RGS16 and RGS-GAIP, but not RGS2, were able to substantially further stimulate the maximal GTPase activity of G(o1)alpha promoted by agonists at the alpha2A-adrenoreceptor in a concentration-dependent manner. Kinetic analysis of the regulation of an alpha2A-adrenoreceptor-G(o1)alpha fusion protein by...

journal_title：Journal of neurochemistry

authors： Hoffmann M,Ward RJ,Cavalli A,Carr IC,Milligan G

更新日期：2001-08-01 00:00:00

abstract：:Muscarinic receptors are the predominant cholinergic receptors in the central and peripheral nervous systems. Recently, activation of muscarinic receptors was found to elicit pigment granule dispersion in retinal pigment epithelium isolated from bluegill fish. Pigment granule movement in retinal pigment epithelium is ...

journal_title：Journal of neurochemistry

authors： Phatarpekar PV,Durdan SF,Copeland CM,Crittenden EL,Neece JD,García DM

更新日期：2005-12-01 00:00:00

abstract：:Highly purified noradrenergic, large, dense-cored vesicles were isolated from bovine sympathetic nerve endings by sucrose-D2O density gradient centrifugation. Their concentration of glycoprotein hexosamine and sialic acid was 6.6 and 3.9 mumol/100 mg lipid-free dry weight, respectively, values which are similar to tho...

journal_title：Journal of neurochemistry

authors： Margolis RU,Ledeen RW,Sbaschnig-Agler M,Byrne MC,Klein RL,Douglas BH 2nd,Margolis RK

更新日期：1987-12-01 00:00:00

abstract：:According to the amyloid hypothesis, accumulation of amyloid beta-peptide (A beta) in the brain is the primary pathogenic event in Alzheimer's disease (AD). Recent evidence indicates that A beta within the intravascular space is linked to A beta deposited in the brain suggesting that transport of A beta between the br...

journal_title：Journal of neurochemistry

authors： Zlokovic BV

更新日期：2004-05-01 00:00:00

abstract：:The carboxyl methylation of secretory proteins in vivo was investigated in bovine adrenal medullary cells in culture. Chromogranin A, the major intragranular secretory protein in adrenal medullary cells, and other secretory proteins were found to be carboxyl-methylated within secretory vesicles. The in vivo labeling p...

journal_title：Journal of neurochemistry

authors： Nguyen MH,Harbour D,Gagnon C

更新日期：1987-07-01 00:00:00

abstract：:The normal cellular prion protein (PrP(C)) is a glycoprotein with two highly conserved potential N-linked glycosylation sites. All prion diseases, whether inherited, infectious or sporadic, are believed to share the same pathogenic mechanism that is based on the conversion of the normal cellular prion protein (PrP(C))...

journal_title：Journal of neurochemistry

authors： Goh AX,Li C,Sy MS,Wong BS

更新日期：2007-02-01 00:00:00

abstract：:The distribution of type I calmodulin-sensitive adenylyl cyclase in bovine and rat tissues was examined by northern blot analysis and in situ hybridization. Northern blot analysis using poly(A)(+)-selected RNA from various bovine tissues indicated that mRNA for type I adenylyl cyclase was found only in brain, retina, ...

journal_title：Journal of neurochemistry

authors： Xia Z,Choi EJ,Wang F,Blazynski C,Storm DR

更新日期：1993-01-01 00:00:00

abstract：:We examined the modulation of nitric oxide production in vivo by measuring levels of nitrite (NO2-) and nitrate (NO3-) in the dialysate of the cerebellum in conscious rats, by using an in vivo brain microdialysis technique. The levels of both NO2- and NO3- were decreased by the intraperitoneal injection of NG-nitro-L-...

journal_title：Journal of neurochemistry

authors： Yamada K,Nabeshima T

更新日期：1997-03-01 00:00:00