Anti-IgG antibodies and antinuclear antibodies in allergic patients.

Abstract:

:With an indirect immunofluorescence technique 77% of 96 patients with type I allergy and 40% of 20 patients with intrinsic bronchial asthma showed positive reactions for IgG anti-IgG antibodies in serum. They were present partly in an aggregated state not directly detectable before treatment with dithiothreitol. The aggregates could be removed by precipitation with polyethylene glycol. The IgG anti-IgG in hyposensitized patients were directed against both F(ab')2 and Fc fragments of rabbit IgG. Thirty of the type I allergic patients were examined once during hyposensitization as well. Before treatment 87% had IgG anti-IgG (titres 9-72). After greater than or equal to 13 months of treatment 100% were positive (titres 36-288). Eight patients were also examined after hyposensitization had been discontinued for at least 12 months. The titres of IgG anti-IgG had then reverted to the levels obtained before hyposensitization. Of 116 controls matched for sex and age, 7% had IgG anti-IgG antibodies. It is suggested that the production of IgG anti-IgG may be stimulated by the presence of immune complexes and that purity, amount and/or combination of allergens administered during hyposensitization may influence the production of anti-IgG antibodies. Neither IgE anti-IgG nor antinuclear antibodies seem to be of particular significance in allergic patients.

journal_name

Allergy

journal_title

Allergy

authors

Egeskjold EM,Permin H,Nielsen I,Sørensen HJ,Osterballe O,Kallerup HE

doi

10.1111/j.1398-9995.1981.tb01875.x

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

573-81

issue

8

eissn

0105-4538

issn

1398-9995

journal_volume

36

pub_type

杂志文章

相关文献

ALLERGY文献大全
  • Storage mite allergy among grain elevator workers.

    abstract::A total of 139 workers (71% of the available work force) in four grain elevator stores in Aalborg, Denmark, participated in a cross-sectional study on the prevalence of storage mite allergy among grain elevator workers. All underwent interview, prick test with a standard panel of allergens and the storage mites Acarus...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1987.tb00357.x

    authors: Revsbech P,Andersen G

    更新日期:1987-08-01 00:00:00

  • Genetic and environmental factors in the changing incidence of allergy.

    abstract::Several studies have indicated that the incidence and prevalence of allergic diseases are increasing. Such data should not be regarded as mere statistical curiosities, but should be analysed to provide information on the factors contributing to allergy and its changing epidemiology. Extensive evidence has been accumul...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1994.tb04232.x

    authors: Bonini S,Magrini L,Rotiroti G,Ronchetti MP,Onorati P

    更新日期:1994-01-01 00:00:00

  • Angioedema induced by cardiovascular drugs: new players join old friends.

    abstract::During the last years, two new cardiovascular drug classes, namely inhibitors of DPP IV or neprilysin, have been developed. In both cases, there is clinical evidence for their potential to induce angioedema as known already from blockers of the renin-angiotensin-aldosterone system (RAAS). The majority of angioedema in...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12680

    authors: Bas M,Greve J,Strassen U,Khosravani F,Hoffmann TK,Kojda G

    更新日期:2015-10-01 00:00:00

  • Airborne pollen levels and drug consumption for seasonal allergic rhinoconjunctivitis: a 10-year study in France.

    abstract:BACKGROUND:Few time-series studies, and none lasting longer than 4 years, have investigated the etiology of treated seasonal allergic rhinoconjunctivitis (SAR) on the basis of anti-allergic medication prescriptions. The aim of this article was to study the short-term relationship between pollen exposure and drug-treate...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.12522

    authors: Caillaud DM,Martin S,Ségala C,Vidal P,Lecadet J,Pellier S,Rouzaire P,Tridon A,Evrard B

    更新日期:2015-01-01 00:00:00

  • Long-term safety of fluticasone furoate nasal spray in adults and adolescents with perennial allergic rhinitis.

    abstract:BACKGROUND:Fluticasone furoate is a novel-enhanced affinity glucocorticoid and its long-term safety must be assessed. This study was designed to assess the safety and tolerability of 12-month intranasal administration of fluticasone furoate in adult and adolescent patients with perennial allergic rhinitis (PAR). METHO...

    journal_title:Allergy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1398-9995.2007.01521.x

    authors: Rosenblut A,Bardin PG,Muller B,Faris MA,Wu WW,Caldwell MF,Fokkens WJ

    更新日期:2007-09-01 00:00:00

  • A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitis.

    abstract:BACKGROUND:Glucocorticoids (GCs) may affect the expression of hundreds of genes in different cells and tissues from patients with intermittent allergic rhinitis (IAR). It is a formidable challenge to understand these complex changes by studying individual genes. In this study, we aimed to identify (i) pathways affected...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2010.02444.x

    authors: Wang H,Chavali S,Mobini R,Muraro A,Barbon F,Boldrin D,Aberg N,Benson M

    更新日期:2011-01-01 00:00:00

  • Hypersensitivity to cefuroxime with good tolerance to other betalactams.

    abstract::A 60-year-old man developed an anaphylactic reaction immediately after administration of intramuscular sodium cefuroxime. By means of oral controlled challenge, the reaction was reproduced with a smaller dose of cefuroxime axetil. Cross-reactivity with other betalactam antibiotics was ruled out by in vivo tests. This ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1995.tb01160.x

    authors: Marcos Bravo C,Luna Ortiz I,González Vázquez R

    更新日期:1995-04-01 00:00:00

  • Management of ocular allergy.

    abstract::The treatment and management of ocular allergy (OA) remain a major concern for different specialties, including allergists, ophthalmologists, primary care physicians, rhinologists, pediatricians, dermatologists, clinical immunologists, and pharmacists. We performed a systematic review of all relevant publications in M...

    journal_title:Allergy

    pub_type: 杂志文章,meta分析

    doi:10.1111/all.13786

    authors: Leonardi A,Silva D,Perez Formigo D,Bozkurt B,Sharma V,Allegri P,Rondon C,Calder V,Ryan D,Kowalski ML,Delgado L,Doan S,Fauquert JL

    更新日期:2019-09-01 00:00:00

  • Periodic fever syndromes: a diagnostic challenge for the allergist.

    abstract::The objective was to present a case of periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA), summarize the medical literature on PFAPA, review the differential diagnosis and suggest a diagnostic approach to periodic fevers in children. A PubMed search was conducted for all case reports an...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/j.1398-9995.2007.01534.x

    authors: Lierl M

    更新日期:2007-12-01 00:00:00

  • Urban/rural differences in diet and atopy in South Africa.

    abstract:BACKGROUND:There are large differences in the prevalence of atopic disease between urban and rural areas of developing countries, without good explanation. Diet has been associated with atopic disease, but studies of specific nutrients are contradictory, cross-sectional studies often being unsupported by trials. We inv...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1398-9995.2008.01627.x

    authors: Hooper R,Calvert J,Thompson RL,Deetlefs ME,Burney P

    更新日期:2008-04-01 00:00:00

  • The effect of dry heat on mite, cat, and dog allergens.

    abstract:BACKGROUND:Various techniques have been tried in an attempt to reduce allergen levels in homes. This study investigated the effect of dry heat on mite, cat, and dog allergens. METHODS:Samples (50 mg) of Dermatophagoides pteronyssinus and D. farinae cultures, and of house dust rich in the major cat and dog allergens Fe...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1998.tb03844.x

    authors: Cain G,Elderfield AJ,Green R,Smillie FI,Chapman MD,Custovic A,Woodcock A

    更新日期:1998-12-01 00:00:00

  • Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.

    abstract::Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the develo...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.14582

    authors: Breiteneder H,Peng YQ,Agache I,Diamant Z,Eiwegger T,Fokkens WJ,Traidl-Hoffmann C,Nadeau K,O'Hehir RE,O'Mahony L,Pfaar O,Torres MJ,Wang DY,Zhang L,Akdis CA

    更新日期:2020-09-07 00:00:00

  • Anaphylactic reaction caused by neoallergens in heated pecan nut.

    abstract::An atopic girl experienced an anaphylactic reaction after eating cookies containing pecan nuts. Investigations revealed that she had developed IgE antibodies exclusively specific against allergenic determinants present in aged or heated pecan nuts, but not in fresh pecans. These neoallergenic determinants were located...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1995.tb02513.x

    authors: Malanin K,Lundberg M,Johansson SG

    更新日期:1995-12-01 00:00:00

  • Human IgE synthesis in vitro. Detection with monoclonal antibodies.

    abstract::Using monoclonal anti-human IgE antibodies recognizing the D epsilon 1 or D epsilon 2 epitope, we have developed a sandwich radioimmunoassay (RIA) to determine IgE in human cell cultures. With the help of this assay, various methods of measuring an actual de novo IgE synthesis were compared. It was necessary to subtra...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1986.tb00327.x

    authors: Knutti-Müller JM,Stadler BM,Magnusson CM,de Weck L

    更新日期:1986-08-01 00:00:00

  • Matrix metalloproteinase-9: a novel biomarker for monitoring disease activity in patients with chronic urticaria patients?

    abstract:BACKGROUND:Matrix metalloproteinase (MMP)-9, an enzyme that contributes to inflammatory responses and subsequent tissue remodelling, has recently been suggested to be a good biomarker for monitoring disease activity in patients with chronic urticaria (CU). Here, we assessed whether total MMP-9 and/or active MMP-9 plasm...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2008.01799.x

    authors: Altrichter S,Boodstein N,Maurer M

    更新日期:2009-04-01 00:00:00

  • IL-5 expression and release from human CD34 cells in vitro; ex vivo evidence from cases of asthma and Churg-Strauss syndrome.

    abstract:BACKGROUND:Eosinophils develop from hematopoietic CD34(+) progenitor cells in the bone marrow (BM) under the influence of Interleukin-5 (IL-5). The primary source of IL-5 is T-lymphocytes, although other sources may exist. The aims of this study were to determine whether CD34(+) cells from human peripheral blood (PB) a...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2009.02271.x

    authors: Bossios A,Sjöstrand M,Dahlborn AK,Samitas K,Malmhäll C,Gaga M,Lötvall J

    更新日期:2010-07-01 00:00:00

  • Plasma separation in patients with bronchial asthma, atopic dermatitis and hyperimmunoglobulinaemia E.

    abstract::The effect of intensive plasma separation performed eight times within 5 weeks in four patients with atopic dermatitis, bronchial asthma and hyperimmunoglobulinaemia E was followed as regards clinical symptoms and changes in the concentrations of serum (S) IgE, S IgG, S IgA, S IgM, plasma complement C3 split products,...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1984.tb01950.x

    authors: Nielsen H,Thomsen B,Djurup R,Søndergaard I,Kappelgaard E,Berkowicz A,Kjersem H,Dahlager JI,Szpirt W,Ullman S

    更新日期:1984-07-01 00:00:00

  • The association between synthetic bedding and adverse respiratory outcomes among skin-prick test positive and skin-prick test negative children.

    abstract:BACKGROUND:Synthetic bedding has been associated with increased child wheeze and also higher allergen levels in several studies. We aimed to examine whether the association between synthetic bedding and adverse respiratory outcomes was more evident among skin-prick test (SPT) positive children. METHODS:A cross-section...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2002.1s3234.x

    authors: Ponsonby AL,Gatenby P,Glasgow N,Mullins R,Hurwitz M,McDonald T

    更新日期:2002-03-01 00:00:00

  • Pulmonary function changes in asthmatics associated with low-level SO2 and NO2 air pollution, weather, and medicine intake. An 8-month prospective study analyzed by neural networks.

    abstract::This paper presents the response in subjects with asthma to gaseous air-pollution levels, weather, and medicine intake as identified by principal-component analysis and neural network techniques. Pulmonary function measured by respiratory peak-flow rate in nonallergic asthmatics was associated with ambient, low-level,...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.1993.tb02402.x

    authors: Moseholm L,Taudorf E,Frøsig A

    更新日期:1993-07-01 00:00:00

  • Prick test: evolution towards automated reading.

    abstract::The prick test is one of the most common medical methods for diagnosing allergies, and it has been carried out in a similar and laborious manner over many decades. In an attempt to standardize the reading of the test, many researchers have tried to automate the process of measuring the allergic reactions found by deve...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12921

    authors: Justo X,Díaz I,Gil JJ,Gastaminza G

    更新日期:2016-08-01 00:00:00

  • The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma.

    abstract::A family of widely expressed ORM-like (ORMDL) proteins has been recently linked to asthma in genomewide association studies in humans and extensively explored in in vivo studies in mice. ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the initial step of sphingolipid biosynthesis...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12877

    authors: Paulenda T,Draber P

    更新日期:2016-07-01 00:00:00

  • Regulatory functions of B cells in allergic diseases.

    abstract::B cells are essentially described for their capacity to produce antibodies ensuring anti-infectious immunity or deleterious responses in the case of autoimmunity or allergy. However, abundant data described their ability to restrain inflammation by diverse mechanisms. In allergy, some regulatory B-cell subsets produci...

    journal_title:Allergy

    pub_type: 杂志文章,评审

    doi:10.1111/all.12490

    authors: Braza F,Chesne J,Castagnet S,Magnan A,Brouard S

    更新日期:2014-11-01 00:00:00

  • Staphylococcus aureus from atopic dermatitis skin accumulates in the lysosomes of keratinocytes with induction of IL-1α secretion via TLR9.

    abstract:BACKGROUND:Staphylococcus aureus (S. aureus) is frequently detected in the skin of patients with atopic dermatitis (AD), and involved in the flare of AD. There are some evidence-specific strains of S. aureus affect the severity of AD. However, the mechanism of predominant colonization and the aggravation of dermatitis ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13622

    authors: Moriwaki M,Iwamoto K,Niitsu Y,Matsushima A,Yanase Y,Hisatsune J,Sugai M,Hide M

    更新日期:2019-03-01 00:00:00

  • Disodium octaborate tetrahydrate (DOT) application and vacuum cleaning, a combined strategy to control house dust mites.

    abstract:BACKGROUND:The effectiveness of acaricides in homes is controversial. OBJECTIVE:To determine whether disodium octaborate tetrahydrate (DOT) combined with vacuuming lowers dust mite numbers and their allergens in carpets and sofas. METHODS:A 6-month study was carried out with 93 homes, which were randomized into three...

    journal_title:Allergy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1398-9995.2003.00100.x

    authors: Codina R,Lockey RF,Diwadkar R,Mobly LL,Godfrey S

    更新日期:2003-04-01 00:00:00

  • Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.

    abstract:BACKGROUND:Dupilumab, a fully human monoclonal antibody that binds IL-4Rα and inhibits signaling of both IL-4 and IL-13, has shown efficacy across multiple diseases with underlying type 2 signatures and is approved for treatment of asthma, atopic dermatitis, and chronic sinusitis with nasal polyposis. We sought to prov...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14151

    authors: Le Floc'h A,Allinne J,Nagashima K,Scott G,Birchard D,Asrat S,Bai Y,Lim WK,Martin J,Huang T,Potocky TB,Kim JH,Rafique A,Papadopoulos NJ,Stahl N,Yancopoulos GD,Murphy AJ,Sleeman MA,Orengo JM

    更新日期:2020-05-01 00:00:00

  • Dominant atopy risk mutations identified by mouse forward genetic analysis.

    abstract:BACKGROUND:Atopy, the overall tendency to become sensitized to an allergen, is heritable but seldom ascribed to mutations within specific genes. Atopic individuals develop abnormally elevated IgE responses to immunization with potential allergens. To gain insight into the genetic causes of atopy, we carried out a forwa...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.14564

    authors: SoRelle JA,Chen Z,Wang J,Yue T,Choi JH,Wang KW,Zhong X,Hildebrand S,Russell J,Scott L,Xu D,Zhan X,Bu CH,Wang T,Choi M,Tang M,Ludwig S,Zhan X,Li X,Moresco EMY,Beutler B

    更新日期:2020-08-18 00:00:00

  • The utility of monitoring trimellitic anhydride (TMA)-specific IgG to predict IgE-mediated sensitization in an immunosurveillance program.

    abstract:BACKGROUND:Workplace exposure to trimellitic anhydride (TMA) can elicit TMA-specific IgE (sIgE), which may lead to occupational asthma (OA). An occupational immunosurveillance program (OISP) has been implemented to monitor TMA exposure and immunologic outcomes. The purpose of this study was to determine whether TMA-spe...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/all.13348

    authors: Ghosh D,Clay C,Bernstein JA

    更新日期:2018-05-01 00:00:00

  • Role of complement in xenotransplantation.

    abstract::The xenotransplantation research is driven by the increasing gap between the number of patients with end-stage organ failure on waiting lists for transplantation and the supply of allografts. The lack of success in developing suitable artificial organs for permanent treatment of organ failure has further strengthened ...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.57.s72.10.x

    authors: Mollnes TE,Fiane AE

    更新日期:2002-01-01 00:00:00

  • Atopy patch test in patients with atopic eczema/dermatitis syndrome: comparison of petrolatum and aqueous solution as a vehicle.

    abstract:BACKGROUND:The atopy patch test (APT) is an in vivo model to study the induction of eczema by inhalant allergens. This study was designed to compare two commonly used APT methods. METHODS:In the first method, the allergen is dissolved in aqueous solution, which is applied on tape-stripped skin. In the second method, t...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1111/j.1398-9995.2003.00379.x

    authors: Oldhoff JM,Bihari IC,Knol EF,Bruijnzeel-Koomen CA,de Bruin-Weller MS

    更新日期:2004-04-01 00:00:00

  • Three cases of childhood nocturnal asthma due to buckwheat allergy.

    abstract:BACKGROUND:Buckwheat flour (BF) is known as a potent food allergen. Sensitization to it usually occurs by ingestion but also by inhalation in occupational or domestic exposure. Buckwheat chaff-stuffed pillows (BCP) can be contaminated with BF during the process of pilling, and many Korean children and adults use BCP fo...

    journal_title:Allergy

    pub_type: 杂志文章

    doi:10.1034/j.1398-9995.2001.056008763.x

    authors: Lee SY,Lee KS,Hong CH,Lee KY

    更新日期:2001-08-01 00:00:00