gamma-Aminobutyric acid antagonists decrease junctional communication between L-horizontal cells of the retina.

abstract：:The functional capacities of CD8(+) T cells important for virus clearance are influenced by interactions with antigen presenting cells (APCs) and CD4(+) T cells during initial selection, subsequent expansion, and development of memory. Recently, investigators have shown that polyfunctional T cells correlate best with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ndhlovu ZM,Oelke M,Schneck JP,Griffin DE

更新日期：2010-02-23 00:00:00

abstract：:Reports of structural differences between the brains of men and women, heterosexual and homosexual men, and male-to-female transsexuals and other men have been offered as evidence that the behavioral differences between these groups are likely caused by differences in the early development of the brain. However, a pos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooke BM,Tabibnia G,Breedlove SM

更新日期：1999-06-22 00:00:00

abstract：:Excitotoxicity, resulting from sustained activation of glutamate receptors of the N-methyl-d-aspartate (NMDA) subtype, is considered to play a causative role in the etiology of ischemic stroke and several neurodegenerative diseases. The NMDA receptor is therefore a target for the development of neuroprotective agents....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tai KK,Blondelle SE,Ostresh JM,Houghten RA,Montal M

更新日期：2001-03-13 00:00:00

abstract：:In an investigation to determine how proteins are localized within the nucleus of a cell, we demonstrate that the restriction endonuclease EcoRI is able to enter and function within the nucleus of Saccharomyces cerevisiae when this prokaryotic protein is synthesized in vivo. The EcoRI endonuclease was produced in yeas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnes G,Rine J

更新日期：1985-03-01 00:00:00

abstract：:Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth after premature birth. We show that lack of insulin-like growth factor I (IGF-I) in knockout mice prevents normal retinal vascular growth, despite the presence of vascular endothelial growth factor, important to vessel devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellstrom A,Perruzzi C,Ju M,Engstrom E,Hard AL,Liu JL,Albertsson-Wikland K,Carlsson B,Niklasson A,Sjodell L,LeRoith D,Senger DR,Smith LE

更新日期：2001-05-08 00:00:00

abstract：:Arf family GTP-binding proteins are best characterized as regulators of membrane traffic, but recent studies indicate an additional role in cytoskeletal organization. An Arf GTPase-activating protein of the centaurin beta family, ASAP1 (also known as centaurin beta4), binds Arf and two other known regulators of the ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randazzo PA,Andrade J,Miura K,Brown MT,Long YQ,Stauffer S,Roller P,Cooper JA

更新日期：2000-04-11 00:00:00

abstract：:Biological invasions contribute to global environmental change, but the dynamics and consequences of most invasions are difficult to assess at regional scales. We deployed an airborne remote sensing system that mapped the location and impacts of five highly invasive plant species across 221,875 ha of Hawaiian ecosyste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asner GP,Hughes RF,Vitousek PM,Knapp DE,Kennedy-Bowdoin T,Boardman J,Martin RE,Eastwood M,Green RO

更新日期：2008-03-18 00:00:00

abstract：:Hapten coupled to isologous gamma globulin can substitute for anti-idiotypic antibody in the induction of neonatal chronic idiotype suppression. The immunologically suppressed animals fail to express an idiotypically defined subset of anti-hapten antibodies in later life and harbor regulatory T cells that prevent the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhisa T,Rajewsky K

更新日期：1985-06-01 00:00:00

abstract：:Food is a powerful entrainment cue for circadian clocks in peripheral tissues, and changes in the composition of nutrients have been demonstrated to metabolically reprogram peripheral clocks. However, how food challenges may influence circadian metabolism of the master clock in the suprachiasmatic nucleus (SCN) or in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tognini P,Samad M,Kinouchi K,Liu Y,Helbling JC,Moisan MP,Eckel-Mahan KL,Baldi P,Sassone-Corsi P

更新日期：2020-11-24 00:00:00

abstract：:Recombinant DNA techniques have been combined with somatic cell genetic methods to identify, isolate, and amplify fragments of human DNA localized at specific regions of human chromosome 11 selected as a model system. A library of genomic DNA segments has been constructed, in lambda Charon 4A bacteriophage, from the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gusella JF,Keys C,VarsanyiBreiner A,Kao FT,Jones C,Puck TT,Housman D

更新日期：1980-05-01 00:00:00

abstract：:A rice Dwarf 1 gene was identified by using a map-based cloning strategy. Its recessive mutant allele confers a dwarf phenotype. Linkage analysis revealed that a cDNA encoding the alpha-subunit of GTP-binding protein cosegregated with d1 in 3,185 d1 segregants. Southern hybridization analysis with this cDNA as a probe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ashikari M,Wu J,Yano M,Sasaki T,Yoshimura A

更新日期：1999-08-31 00:00:00

abstract：:Infection with avian influenza A virus of the H5N1 subtype (isolates A/HK/212/03 and A/HK/213/03) was fatal to one of two members of a family in southern China in 2003. This incident was preceded by lethal outbreaks of H5N1 influenza in waterfowl, which are the natural hosts of these viruses and, therefore, normally h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan Y,Poon LL,Cheung CY,Ellis TM,Lim W,Lipatov AS,Chan KH,Sturm-Ramirez KM,Cheung CL,Leung YH,Yuen KY,Webster RG,Peiris JS

更新日期：2004-05-25 00:00:00

abstract：:Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine's antidepressant and adverse effects, the potency of (2R,6R)-HNK to inhibit NMDARs has not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lumsden EW,Troppoli TA,Myers SJ,Zanos P,Aracava Y,Kehr J,Lovett J,Kim S,Wang FH,Schmidt S,Jenne CE,Yuan P,Morris PJ,Thomas CJ,Zarate CA Jr,Moaddel R,Traynelis SF,Pereira EFR,Thompson SM,Albuquerque EX,Gould TD

更新日期：2019-03-12 00:00:00

abstract：:The origin of highly magnetized white dwarfs has remained a mystery since their initial discovery. Recent observations indicate that the formation of high-field magnetic white dwarfs is intimately related to strong binary interactions during post-main-sequence phases of stellar evolution. If a low-mass companion, such...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nordhaus J,Wellons S,Spiegel DS,Metzger BD,Blackman EG

更新日期：2011-02-22 00:00:00

abstract：:Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabies glycoprotein recombinant virus in a sponge bait developed rabies virus-neutralizing antibody (0.6-54.0 units) and resisted street r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rupprecht CE,Wiktor TJ,Johnston DH,Hamir AN,Dietzschold B,Wunner WH,Glickman LT,Koprowski H

更新日期：1986-10-01 00:00:00

abstract：:The bacteriophage T4-encoded RegB endoribonuclease is produced during the early stage of phage development and targets mostly (but not exclusively) the Shine-Dalgarno sequences of early genes. In this work, we show that the degradation of RegB-cleaved mRNAs depends on a functional T4 polynucleotide kinase/phosphatase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Durand S,Richard G,Bontems F,Uzan M

更新日期：2012-05-01 00:00:00

abstract：:The retrosplenial cortex (RSC) is part of a network of interconnected cortical, hippocampal, and thalamic structures harboring spatially modulated neurons. The RSC contains head direction cells and connects to the parahippocampal region and anterior thalamus. Manipulations of the RSC can affect spatial and contextual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czajkowski R,Jayaprakash B,Wiltgen B,Rogerson T,Guzman-Karlsson MC,Barth AL,Trachtenberg JT,Silva AJ

更新日期：2014-06-10 00:00:00

abstract：:The rpoN gene encoding the transcription factor sigma54 in Myxococcus xanthus has been cloned using a heterologous rpoN probe. The sequence of the cross-hybridizing DNA confirmed the existence of an ORF 1518 bp long that encodes a well conserved member of the sigma54 family of sigma factors. Low- as well as high-strin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keseler IM,Kaiser D

更新日期：1997-03-04 00:00:00

abstract：:A sequence of 14 nucleotides in one human diversity (D) minigene (D2) is identical with a sequence in complementarity-determining region 2 (CDR2) of one human gene for the variable region of the heavy chain of immunoglobulin. The finding that nucleotide segments present in a D minigene can appear in CDR2 raises the po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TT,Kabat EA

更新日期：1982-08-01 00:00:00

abstract：:We noticed that disease-related amyloidogenic proteins and especially cellular prion proteins have the highest proportion of incompletely desolvated backbone H bonds among soluble proteins. Such bonds are vulnerable to water attack and thus represent structural weaknesses. We have measured the adsorption of proteins o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Berry RS

更新日期：2003-03-04 00:00:00

abstract：:Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC). VEGF in mice is produced as three isoforms, VEGF120, VEGF164, and VEGF188, that differ in their ability to bind heparan sulfate proteoglycan. RPE normally pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saint-Geniez M,Kurihara T,Sekiyama E,Maldonado AE,D'Amore PA

更新日期：2009-11-03 00:00:00

abstract：:Explanations for primate brain expansion and the evolution of human cognition and culture remain contentious despite extensive research. While multiple comparative analyses have investigated variation in brain size across primate species, very few have addressed why primates vary in how much they use social learning. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Street SE,Navarrete AF,Reader SM,Laland KN

更新日期：2017-07-25 00:00:00

abstract：:Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the solution structure of the cysteine/histidine-rich 1 (CH1) domain of p300 bound to the C-terminal transactivation domain of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freedman SJ,Sun ZY,Poy F,Kung AL,Livingston DM,Wagner G,Eck MJ

更新日期：2002-04-16 00:00:00

abstract：:The lectin chaperone calreticulin (CRT) assists the folding and quality control of newly synthesized glycoproteins in the endoplasmic reticulum (ER). It interacts with ERp57, a thiol-disulfide oxidoreductase that promotes the formation of disulfide bonds in glycoproteins bound by CRT. Here, we investigated the interac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frickel EM,Riek R,Jelesarov I,Helenius A,Wuthrich K,Ellgaard L

更新日期：2002-02-19 00:00:00

abstract：:Maintenance of genome stability is essential for the accurate propagation of genetic information and cell growth and survival. Organisms have therefore developed efficient strategies to prevent DNA lesions and rearrangements. Much of the information concerning these strategies has been obtained through the study of ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maréchal A,Parent JS,Véronneau-Lafortune F,Joyeux A,Lang BF,Brisson N

更新日期：2009-08-25 00:00:00

abstract：:The DNA binding activity of p53 is crucial for its tumor suppressor function and is subject to tight regulation. Previous studies revealed that the inhibitory function of the p53 C terminus is implicated in the latent, low affinity sequence-specific DNA binding activity of p53 in the uninduced state. Sequence-specific...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller-Tiemann BF,Halazonetis TD,Elting JJ

更新日期：1998-05-26 00:00:00

abstract：:The role of microtubules in 3H-labeled protein secretion in rat lacrimal glands was probed by the use of colchicine and two of its analogues that reversibly bind to tubulin. These analogues were 2-methoxy-5-(2,3,4,4'-trimethoxyphenyl)-2,4,6-cycloheptatriene-1-o ne and 2,3,4,4'-tetramethoxy-1,1'-biphenyl, the latter ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herman G,Busson S,Gorbunoff MJ,Mauduit P,Timasheff SN,Rossignol B

更新日期：1989-06-01 00:00:00

abstract：:We report the cloning and characterization of a cancer-associated cell membrane glycoprotein recognized by mAb NCC-3G10. The antibody showed strong reactivity to a wide variety of cancer cells, but only to a limited number of normal cells including lymphocytes, endothelial cells, and basal cells of stratified squamous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ino Y,Gotoh M,Sakamoto M,Tsukagoshi K,Hirohashi S

更新日期：2002-01-08 00:00:00

abstract：:A four-factor cross between two strains of Phycomyces involving two auxotrophic, one color, and the mating type marker is described. Samples of 40 germspores from 84 individual fertile germsporangia were characterized. The results show: (i) The germspores of a germsporangium are derived from one meiosis in approximate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eslava AP,Alvarez MI,Delbrück M

更新日期：1975-10-01 00:00:00

abstract：:The c-fos protooncogene is transcriptionally activated by a wide variety of agents including serum, growth factors, and phorbol esters. This induction is rapid and transient and is mediated through a number of identified promoter elements. Growth hormone (GH) is also known to induce transcription of c-fos in a variety...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer DJ,Stephenson EW,Johnson L,Cochran BH,Schwartz J

更新日期：1993-07-15 00:00:00