Further study of the inhibition of premature labor by indomethacin. Part I.

Abstract:

:Prematurity still remains one of the unsolved problems in obstetrics and is responsible for a majority of cases of perinatal morbidity and mortality. The use of indomethacin to stop uterine contractions and prevent premature delivery is based on the observation that indomethacin inhibits the release of prostaglandin which is assumed to play a role in the induction and continuation of labor. The effect of indomethacin as an antagonist to prostaglandin was evaluated in a series of 297 women in premature labor. The gestational age at admission varied between 24 and 34 weeks of pregnancy (120 primiparas and 177 multiparas). In 83% of cases there was complete cessation of labor for a period of 1 to 12 weeks, in 10% of cases from 2 to 7 days and in 7% there was no effect. The delay of premature labor for 2 to 7 days allowed the administration of betamethasone in an attempt to improve fetal lung maturity. The total daily dose needed for successful treatment was between 200-300 mg indomethacin. Dilation of cervix beyond 4 cm was associated with successful treatment in 58% compared to 90% if cervix was dilated 3 cm or less. In comparing women with intact membranes to women with ruptured, the success rate in suppressing premature labor was significant; 88% versus 53%. In 49 patients delivery was delayed 11-12 weeks. Fifty-one babies were born in spite of therapy, and of these 15 with birth weights of 700-1500 g suffered from respiratory distress syndrome and died. All the rest (36 premature and 246 mature infants) showed no ill effects related to the treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Perinat Med

authors

Zuckerman H,Shalev E,Gilad G,Katzuni E

doi

10.1515/jpme.1984.12.1.19

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

19-23

issue

1

eissn

0300-5577

issn

1619-3997

journal_volume

12

pub_type

杂志文章
  • Growth attainment in German children born preterm, and cardiovascular risk factors in adolescence. Analysis of the population representative KiGGS data.

    abstract:AIM:To compare the growth attainment of preterm children and their cardiovascular risk factors at adolescence with the values measured in term children in Germany. METHODS:About 17,641 children aged 0 to <18 years were studied between 2003 and 2006 in the population representative German KiGGS survey ("German Health I...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2016-0294

    authors: Bergmann RL,Bergmann KE,Richter R,Schlaud M,Henrich W,Weichert A

    更新日期:2017-07-26 00:00:00

  • Effect of blood on ROM diagnosis accuracy of PAMG-1 and IGFBP-1 detecting rapid tests.

    abstract::Vaginal bleeding may be present in up to 30% of patients presenting with signs and symptoms of a rupture of the fetal membranes (ROM). The presence of blood may lead to false positive results with biochemical markers. The data presented in this study came from a multi-centric prospective observational clinical study t...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1515/jpm-2014-0227

    authors: Ramsauer B,Duwe W,Schlehe B,Pitts R,Wagner D,Wutkewicz K,Chuvashkin D,Abele H,Lachmann R

    更新日期:2015-07-01 00:00:00

  • Correlates of the trend of cesarean section rates in twin pregnancies.

    abstract:OBJECTIVE:To examine the population-based trend for cesarean births in twin pregnancies for the last 13 years in Slovenia, and to find correlates for this trend. METHODS:We evaluated data from the Slovenian national perinatal information system (NPIS) of all twin pairs born at ≥24 weeks during the period 1997-2009 (n=...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2011.129

    authors: Tul N,Verdenik I,Trojner-Bregar A,Novak Ž,Blickstein I

    更新日期:2012-04-01 00:00:00

  • Thrombocytopoiesis in healthy term newborns.

    abstract:AIMS:Thrombocytopoiesis was investigated in term newborns determining thrombopoietin (TPO), reticulated platelets (PLRET) and blood platelets (PLT) in relation to gender. PATIENTS AND METHODS:The study was undertaken on 72 healthy term newborns, 33 girls and 39 boys. They fitted all criteria for healthy term newborns....

    journal_title:Journal of perinatal medicine

    pub_type: 临床试验,杂志文章

    doi:10.1515/JPM.2005.046

    authors: Wasiluk A

    更新日期:2005-01-01 00:00:00

  • Optimization of human milk fortification for preterm infants: new concepts and recommendations.

    abstract::Preterm infants fed fortified human milk (HM) in standard (STD) fashion grow slower than preterm formula fed infants. Recently, low protein intake has been proven to be the primary limiting factor responsible for this growth failure. The main reason of protein undernutrition despite fortification is that STD fortifica...

    journal_title:Journal of perinatal medicine

    pub_type: 指南,杂志文章

    doi:10.1515/jpm.2010.073

    authors: Arslanoglu S,Moro GE,Ziegler EE,The Wapm Working Group On Nutrition

    更新日期:2010-05-01 00:00:00

  • The use of culture-independent tools to characterize bacteria in endo-tracheal aspirates from pre-term infants at risk of bronchopulmonary dysplasia.

    abstract::Although premature infants are increasingly surviving the neonatal period, up to one-third develop bronchopulmonary dysplasia (BPD). Despite evidence that bacterial colonization of the neonatal respiratory tract by certain bacteria may be a risk factor in BPD development, little is known about the role these bacteria ...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm.2010.026

    authors: Stressmann FA,Connett GJ,Goss K,Kollamparambil TG,Patel N,Payne MS,Puddy V,Legg J,Bruce KD,Rogers GB

    更新日期:2010-05-01 00:00:00

  • Justified skepticism about Apgar scoring in out-of-hospital birth settings.

    abstract:BACKGROUND:The Apgar score is used worldwide to assess the newborn infant shortly after birth. Apgar scores, including mean scores and those with high cut-off scores, have been used to support claims that planned home birth is as safe as hospital birth. The purpose of this study was to determine the distribution of 5 m...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2014-0003

    authors: Grünebaum A,McCullough LB,Brent RL,Arabin B,Levene MI,Chervenak FA

    更新日期:2015-07-01 00:00:00

  • Endocervical immune mediator production following successful rescue or ultrasound indicated cerclage placement.

    abstract:OBJECTIVE:Placement of a cervical cerclage at mid-trimester in women at risk for preterm labor is a common procedure with apparent benefits for some women. However, the changes that occur in the cervix following this procedure remain incompletely identified. METHODS:We evaluated the endocervical concentrations of medi...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2011.132

    authors: Kanninen TT,Herway C,Skupski DW,Eglinton GS,Witkin SS

    更新日期:2011-11-25 00:00:00

  • A randomized trial of cerclage vs. 17 alpha-hydroxyprogesterone caproate for treatment of short cervix.

    abstract:OBJECTIVE:To determine pregnancy outcome in patients with short cervix on transvaginal ultrasound between 16 and 24 weeks' gestation treated with McDonald cerclage compared to weekly intramuscular injections of 17 alpha-hydroxyprogesterone caproate (17OHP-C). METHODS:From November 2003 through December 2006, asymptoma...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1515/JPM.2009.083

    authors: Keeler SM,Kiefer D,Rochon M,Quinones JN,Novetsky AP,Rust O

    更新日期:2009-01-01 00:00:00

  • Weight gain and dietary intake during pregnancy in industrialized countries--a systematic review of observational studies.

    abstract:BACKGROUND:Gestational weight gain (GWG) above the recently recommended ranges is likely to be related to adverse pregnancy outcomes and therefore a challenge in industrialized countries. AIMS:We conducted a systematic review on observational studies in order to gain more evidence on whether diets with lower caloric/p...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/jpm.2010.127

    authors: Streuling I,Beyerlein A,Rosenfeld E,Schukat B,von Kries R

    更新日期:2011-03-01 00:00:00

  • The effects of Betamethasone on white blood cells during pregnancy with PPROM.

    abstract:OBJECTIVE:To determine the effects of Betamethasone injections on maternal white blood cell counts. STUDY DESIGN:Thirteen pregnant women without fever or clinical infection and with premature rupture of the membranes at less than 34 weeks gestation were studied. No subject had labor during the week of study. Daily com...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1998.26.3.204

    authors: Diebel ND,Parsons MT,Spellacy WN

    更新日期:1998-01-01 00:00:00

  • Twin fetal facial expressions at 30-33+6 weeks of gestation.

    abstract::Objective To assess the characteristics of twin fetal facial expressions at 30-33 + 6 weeks of gestation using four-dimensional (4D) ultrasound to clarify twin fetal brain development and maturation. Methods Frequencies of seven fetal facial expressions were studied using 4D ultrasound for 15 minutes in 30 singleton p...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2019-0127

    authors: Nitta E,Kanenishi K,Mori N,AboEllail MAM,Hata T

    更新日期:2019-11-26 00:00:00

  • The impact of length of second stage of labor on shoulder dystocia outcomes: a retrospective cohort study.

    abstract:OBJECTIVE:To compare obstetrical and neonatal outcomes of vaginal deliveries complicated by shoulder dystocia, according to the length of second stage of labor. METHODS:We conducted a retrospective cohort study of 177 shoulder dystocia cases that were divided into three categories according to second stage duration (1...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2011-0253

    authors: Moragianni VA,Hacker MR,Craparo FJ

    更新日期:2012-03-29 00:00:00

  • The evidence linking maternal nutrition and prematurity.

    abstract::Maternal nutrition may be one of the most important under-evaluated factors contributing to the contemporary rise in prematurity in the United States and other industrialized nations around the world. Slowed fetal growth has been repeatedly shown to be associated with preterm birth, in both singleton and twin pregnanc...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/JPM.2005.088

    authors: Luke B

    更新日期:2005-01-01 00:00:00

  • Intrapartum prediction of birth weight with a simplified algorithmic approach derived from maternal characteristics.

    abstract::Objective To derive and validate a population-specific multivariate approach for birth weight (BW) prediction based on quantitative intrapartum assessment of maternal characteristics by means of an algorithmic method in low-risk women. Methods The derivation part (n = 200) prospectively explored 10 variables to create...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2018-0347

    authors: Yapan P,Promchirachote C,Yaiyiam C,Rahman S,Pooliam J,Wataganara T

    更新日期:2019-08-27 00:00:00

  • Influence of non-pharmacological obstetric interventions on adverse outcomes of childbirth under regional analgesia.

    abstract::Background We examined the influence of companionship and the use of complementary therapies on adverse outcomes in parturients under regional analgesia. Methods This study is a single-center retrospective cohort of 986 term pregnant women, and it was based on data from medical records (hospitalization period: Novembe...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2019-0366

    authors: Gribel GPC,Coca-Velarde LG,Moreira de Sá RA

    更新日期:2020-06-25 00:00:00

  • Excretion of ketobemidone in human breast milk.

    abstract::The excretion of ketobemidone into human breast milk was investigated in three women who obtained ketobemidone as postoperative pain relief after Cesarean section and two women premedicated with 5 mg of ketobemidone before currettage after delivery. The highest observed concentration of ketobemidone in breast milk was...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1996.24.3.293

    authors: Gerdin E,Bondesson U,Hartvig P

    更新日期:1996-01-01 00:00:00

  • Limit of viability in Japan: ethical consideration.

    abstract::Viability means "the quality or state of being able to live, grow and develop." Limit of viability has been changed along with the advancement of perinatal and neonatal medicine. The viability limit defined in the Japanese Motherhood Protection Act was amended from 24 to 22 completed weeks of gestation in 1991 based o...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/JPM.2009.112

    authors: Nishida H,Sakuma I

    更新日期:2009-01-01 00:00:00

  • Iron homeostasis after blood transfusion in stable preterm infants - an observational study.

    abstract:AIM:To evaluate the short-term effects of blood transfusion on iron status [hemoglobin, ferritin, soluble transferrin receptor (sTfR), and reticulocyte count], hepcidin, and erythropoietin in stable preterm infants. METHOD:Sixty-three preterm infants treated with red blood cell transfusions (RBCTs) were included. Veno...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2015-0361

    authors: Herzlich J,Litmanovitz I,Regev R,Bauer S,Sirota G,Steiner Z,Arnon S

    更新日期:2016-10-01 00:00:00

  • Oral glucose tolerance test is a poor predictor of hyperglycemia during pregnancy.

    abstract::In an effort to assess the efficacy of the oral glucose tolerance test to detect patients with gestational diabetes mellitus who require therapeutic measures to maintain normoglycemia, we compared the results of an oral glucose tolerance test with those of a home glucose profile consisting of three postprandial glucos...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1989.17.4.253

    authors: Backx CJ,Lotgering FK,Cornelis H,Wallenburg S

    更新日期:1989-01-01 00:00:00

  • A comparison of postoperative morbidity following prophylactic antibiotic administration by combined irrigation and intravenous route or by intravenous route alone during cesarean section.

    abstract::This study compared the efficacy of a single intravenous dose of Cefazolin alone or combined with an antibiotic containing preclosure-irrigation solution in patients undergoing cesarean section. A total of 308 patients were prospectively assigned to two groups by randomization. Group I received two grams of Cefazolin ...

    journal_title:Journal of perinatal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1515/jpme.1992.20.3.177

    authors: Mathelier AC

    更新日期:1992-01-01 00:00:00

  • A microcomputer data base system for maternal serum alpha fetoprotein screening programmed in BASIC.

    abstract::A computer program was developed for the IBM PC computer to be used for maternal serum alpha fetoprotein screening (MSAFP). This program, written in BASIC, 1) maintains a data base for patients tested, 2) allows input and storage of MSAFP results, 3) calculates the gestational age dependent result in multiple of the m...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1989.17.3.221

    authors: Keel BA,Durfee KK,Cho S

    更新日期:1989-01-01 00:00:00

  • Fetal lung maturity evaluation with fluorescence polarization of the amniotic fluid.

    abstract::Fluorescence polarization of the amniotic fluid from 39 high risk pregnancies requiring preterm delivery was measured in order to assess the maturity of the fetal lung. The study population included 15 cases of intrauterine growth retardation, ten maternal hypertension, five maternal Hodgkin's disease, three placenta ...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1993.21.5.349

    authors: Salmona M,Diomede L,Moro G,Minoli I,Bernini S,Agosti S

    更新日期:1993-01-01 00:00:00

  • New scoring system for fetal neurobehavior assessed by three- and four-dimensional sonography.

    abstract:AIM:To produce a new scoring system for fetal neurobehavior based on prenatal assessment by 3D/4D sonography. We identified severely brain damaged infants and those with optimal neurological findings and compared fetal with neonatal findings. RESULTS:The new scoring system was retrospectively applied in a group of 100...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2008.007

    authors: Kurjak A,Miskovic B,Stanojevic M,Amiel-Tison C,Ahmed B,Azumendi G,Vasilj O,Andonotopo W,Turudic T,Salihagic-Kadic A

    更新日期:2008-01-01 00:00:00

  • Erythrocyte deformability of nonpregnant, pregnant, and fetal blood.

    abstract::Erythrocyte deformability is an important determinant of microcirculation, of oxygen transport and release to the tissue. In an attempt to clarify the rheological peculiarity during pregnancy, erythrocyte deformability was measured in 10 nonpregnant controls and 10 pairs of mothers and newborns. When the hematocrit of...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1995.23.4.301

    authors: Eguchi K,Sawai T,Mizutani Y

    更新日期:1995-01-01 00:00:00

  • Meconium peritonitis secondary to torsion of fallopian tube cyst and transient central diabetes insipidus in a preterm infant.

    abstract::Meconium peritonitis is a sterile chemical peritonitis caused by peritoneal seeding of meconium from an antenatal gastrointestinal perforation. We report a 32-week preterm female neonate who developed meconium peritonitis due to bowel perforation, secondary to a twisted left fallopian tube mass, which was excised and ...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2005.014

    authors: Manikoth P,Vaishnav A,Zachariah N,Sajwani MJ,Nair AK,Pai MG

    更新日期:2005-01-01 00:00:00

  • Cardiotocography patterns and risk of intrapartum fetal acidemia.

    abstract:AIM:To identify cardiotocography (CTG) patterns associated with increased risk of intrapartum fetal acidemia. METHODS:A prospective observational cohort study of 1070 women with fetal scalp blood sampling (FBS) during labor was conducted at Karolinska University Hospital, Stockholm, Sweden. Women with a nonreassuring ...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpm-2014-0105

    authors: Holzmann M,Wretler S,Cnattingius S,Nordström L

    更新日期:2015-07-01 00:00:00

  • Listeriosis in human pregnancy: a systematic review.

    abstract::Listeria is commonly found in processed and prepared foods and listeriosis is associated with high morbidity and mortality. Preventative measures are well prescribed and monitoring and voluntary recall of contaminated products has resulted in a 44% reduction in the prevalence of perinatal listeriosis in the USA. Pregn...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章,评审

    doi:10.1515/jpm.2011.035

    authors: Lamont RF,Sobel J,Mazaki-Tovi S,Kusanovic JP,Vaisbuch E,Kim SK,Uldbjerg N,Romero R

    更新日期:2011-05-01 00:00:00

  • No difference between home and clinic blood pressure measurements in pregnancy: a computerized telemetric study.

    abstract::Many decisions in pregnancy are based on one or two casual blood pressure estimations made in the antenatal clinic. No previous study has challenged the validity of this practice or attempted to discover whether there are significant differences between the blood pressures of pregnant women when they are measured in t...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/jpme.1991.19.1-2.133

    authors: Mooney P,Jaspar A,Cartwright W,Swindells HE,Dalton KJ

    更新日期:1991-01-01 00:00:00

  • Two-dimensional and three-dimensional ultrasound of fetal anasarca: the glass baby.

    abstract::Fetal edema was recognized in the past as a complication of alloimmune disease. More recently, fetal edema is frequently seen in conditions that cause non-immune fetal hydrops with increased soft tissue thickness. Classically there is a halo pattern around fetal head, neck, thorax, and abdomen. Fetal edema is associat...

    journal_title:Journal of perinatal medicine

    pub_type: 杂志文章

    doi:10.1515/JPM.2002.013

    authors: Machado LE,Osborne NG,Bonilla-Musoles F

    更新日期:2002-01-01 00:00:00