Pulmonary lymphangiomyomatosis: with particular reference to steroid-receptor assay studies and pathologic correlation.

Abstract:

:The symptoms of progressive dyspnea, hemoptysis, spontaneous pneumothorax, chylous effusions, and cough in conjunction with ventilatory obstruction and abnormal gas exchange in a young woman should prompt the diagnosis of pulmonary lymphangiomyomatosis. Cytosol steroid-receptor assays and postmortem studies were conducted in an extensive investigation of a case of this disease. A biopsy specimen of the lung disclosed evidence of nuclear translocation of [3H]progesterone and the presence of a cytosolic receptor for progesterone, an indication that this disease could be treated effectively with progestin.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Graham ML 2nd,Spelsberg TC,Dines DE,Payne WS,Bjornsson J,Lie JT

doi

10.1016/s0025-6196(12)60333-4

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

3-11

issue

1

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(12)60333-4

journal_volume

59

pub_type

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