Issues concerning androgen replacement therapy in postmenopausal women.

Abstract:

:A decrease in blood androgen levels is well documented in women who experience natural or surgical menopause. This change may be associated with various negative effects on bone metabolism in addition to psychosocial and sexuality aspects of life. A review of published information on androgen replacement therapy shows that major benefits may be achieved; unfortunately, only minimal quality information is available to help clinicians make decisions about this type of therapy. In this review, we point out the potential benefits and risks to bone, lipid and carbohydrate metabolism, and sexuality; in addition, we discuss potential risks of neoplasms and virilizing somatic changes. Long-term, physiologic, and well-designed androgen replacement studies should be performed to obtain the knowledge needed to guide therapy in this important area.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Abraham D,Carpenter PC

doi

10.4065/72.11.1051

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

1051-5

issue

11

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)63546-5

journal_volume

72

pub_type

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