Intra-coronary thrombolysis with streptokinase or lys-plasminogen/urokinase in acute myocardial infarction: effects on recanalization and blood fibrinolysis.

abstract：:Recent clinical studies have shown that the interruption of platelet function appears to be effective for treatment of coronary occlusive diseases. For this purpose, a Fab fragment of humanized anti-platelet glycoprotein (GP) IIb/IIIa monoclonal antibody (YM 337) that exhibited an in vivo antithrombotic effect without...

journal_title：Thrombosis and haemostasis

authors： Kuwahara M,Sugimoto M,Tsuji S,Miyata S,Nishio K,Kaku S,Suzuki K,Kawasaki T,Yoshioka A

更新日期：1998-07-01 00:00:00

abstract：:Normal adults have very few circulating endothelial cells (CECs) in their blood, but increased levels have been shown in association with conditions associated with endothelial damage such as myocardial infarction and stroke. As atrial fibrillation (AF) is associated with a hypercoagulable state and abnormalities of p...

journal_title：Thrombosis and haemostasis

authors： Freestone B,Lip GY,Chong AY,Nadar S,Lee KW,Blann AD

更新日期：2005-10-01 00:00:00

abstract：:Prothrombin complex concentrates (PCCs) and fresh-frozen plasma (FFP) have been clinically used for acute warfarin reversal. The recovery of prothrombin time (PT) or international normalised ratio (INR) is often reported as an endpoint, but haemostatic efficacies of PCCs and FFP may not be fully reflected in static cl...

journal_title：Thrombosis and haemostasis

authors： Ogawa S,Szlam F,Ohnishi T,Molinaro RJ,Hosokawa K,Tanaka KA

更新日期：2011-12-01 00:00:00

abstract：:Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associate...

journal_title：Thrombosis and haemostasis

authors： Boehlen F,Casini A,Chizzolini C,Mansouri B,Kohler HP,Schroeder V,Reber G,de Moerloose P

更新日期：2013-03-01 00:00:00

abstract：:The aim was to investigate the perioperative risk of ischaemic and bleeding events in patients with coronary stents undergoing cardiac and non-cardiac surgery and how these outcomes are affected by the perioperative use of oral antiplatelet therapy. This was a multicentre, retrospective, observational study conducted ...

journal_title：Thrombosis and haemostasis

authors： Rossini R,Musumeci G,Capodanno D,Lettieri C,Limbruno U,Tarantini G,Russo N,Calabria P,Romano M,Inashvili A,Sirbu V,Guagliumi G,Valsecchi O,Senni M,Gavazzi A,Angiolillo DJ

更新日期：2015-02-01 00:00:00

abstract：:Using an in vitro model of clot lysis, the individual response to a pharmacological concentration of recombinant tissue plasminogen activator (rt-PA) and the influence on this response of the physiological variations of blood parameters known to interfere with the fibrinolytic/thrombolytic process were investigated in...

journal_title：Thrombosis and haemostasis

authors： Colucci M,Scopece S,Gelato AV,Dimonte D,Semeraro N

更新日期：1997-04-01 00:00:00

abstract：:Antithrombin readily undergoes a spontaneous transition from its active five-stranded form to a six-stranded inactive latent form. The recognition of this change in plasma has been obscured by the immediate linkage of newly formed latent antithrombin to a molecule of active antithrombin to give a dimer with an electro...

journal_title：Thrombosis and haemostasis

authors： Carrell RW,Huntington JA,Mushunje A,Zhou A

更新日期：2001-07-01 00:00:00

abstract：:Components of the fibrinolytic system were studied in samples of plasma from 15 normal, young women and from 11 women taking oral contraceptives containing 30 micrograms ethinyl oestradiol and 150 micrograms levo-norgestrel. Fibrinolytic activity of euglobulins precipitated at pH 5.9 was higher than normal in the horm...

journal_title：Thrombosis and haemostasis

authors： Jespersen J,Kluft C

更新日期：1985-08-30 00:00:00

abstract：:The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the se...

journal_title：Thrombosis and haemostasis

authors： Landi D,Beckman MG,Shah NR,Bockenstedt P,Grant AM,Heit JA,Key NS,Kulkarni R,Manco-Johnson M,Moll S,Philipp CS,Andersen JC,Ortel TL

更新日期：2013-04-01 00:00:00

abstract：:The role of platelets in regulating vascular homeostasis has expanded beyond mediation of haemostasis and thrombosis. The discovery of platelet RNA and the presence of subpopulations of platelets containing varying amounts of RNA suggest a role for platelet transcripts in vascular function. As the RNA in anucleated pl...

journal_title：Thrombosis and haemostasis

authors： Clancy L,Beaulieu LM,Tanriverdi K,Freedman JE

更新日期：2017-05-03 00:00:00

abstract：:This study was performed to follow up on the observation that gelatinase A (MMP-2) deficiency impairs adipose tissue development in mice. The aim was to evaluate the role of its functional homologue gelatinase B (MMP-9) in adipose tissue growth. MMP-9 antigen levels were determined in lean and in obese women before an...

journal_title：Thrombosis and haemostasis

authors： Van Hul M,Piccard H,Lijnen HR

更新日期：2010-07-01 00:00:00

abstract：:Warfarin induction is accomplished by titrating dosage to coagulation test results. Algorithms can guide this process but not identify the starting dose. We hypothesized that an initial warfarin dose approximating the maintenance value would safely enhance rapidity of induction. In a randomized trial we compared a fix...

journal_title：Thrombosis and haemostasis

authors： Shine D,Patel J,Kumar J,Malik A,Jaeger J,Maida M,Ord L,Burrows G

更新日期：2003-02-01 00:00:00

abstract：:To investigate the inhibitory mechanism of tissue factor pathway inhibitor (TFPI), an attempt was made to examine the inhibitory activity of TFPI toward the factor VIIa-truncated tissue factor (TF1-219) complex, which lacks its transmembrane and cytoplasmic domains. Factor VIIa-TF1-219 activity was significantly inhib...

journal_title：Thrombosis and haemostasis

authors： Kazama Y

更新日期：1997-03-01 00:00:00

abstract：:The preparation of antithrombin concentrate for clinical use requires a viral inactivation step. In most commercial preparations this is achieved by heat pasteurisation. This process would be expected to alter the conformation of antithrombin from the active native species to an inactive latent (L-form) state (1, 2). ...

journal_title：Thrombosis and haemostasis

authors： Chang WS,Harper PL

更新日期：1997-02-01 00:00:00

abstract：:Autoantibodies to the zwitterionic phospholipid (PL), phosphatidylethanolamine (PE) have been described in patients with thrombotic diseases. Recently, we reported that many antiphosphatidylethanolamine antibodies (aPE) are not specific for PE per se, but are directed to plasma proteins which can bind PE, for example,...

journal_title：Thrombosis and haemostasis

authors： Sugi T,Mclntyre JA

更新日期：1996-09-01 00:00:00

abstract：:Washed human platelets have been labeled with either 32Pi or glycerol-1-14C and the distribution of the label in the phospholipids determined. 32Pi was introduced primarily into polyphosphoinositides, i.e. di- and triphosphoinositide, whereas the label from glycerol which indicates de novo synthesis of lipid molecules...

journal_title：Thrombosis and haemostasis

authors： Kaulen HD,Gross R

更新日期：1976-04-30 00:00:00

abstract：:Two novel polymorphisms were identified in the factor V gene by direct sequencing of intronic areas. One of them, located in intron 9, is the marker closest to the Leiden mutation ever described, whereas the other, in intron 16, displays a rare allele invariantly associated to the mutation. Allele-specific amplificati...

journal_title：Thrombosis and haemostasis

authors： Castoldi E,Lunghi B,Mingozzi F,Ioannou P,Marchetti G,Bernardi F

更新日期：1997-09-01 00:00:00

abstract：:A four-decade clinical experience and recent evidence from randomised controlled studies definitively recognised primary prophylaxis, i.e. the regular infusion of factor concentrates started after the first haemarthrosis and/or before the age of two years, as the first-choice treatment in children with severe haemophi...

journal_title：Thrombosis and haemostasis

authors： Coppola A,Franchini M,Tagliaferri A

更新日期：2009-04-01 00:00:00

abstract：:Cardiovascular diseases are a major cause of mortality in the developed world. Efficacy of thrombolysis plays an important role in the management of acute myocardial infarction and cerebral insult both in the acute event and in the long-term outcome of these patients. New adjunctive strategies have been tested, theref...

journal_title：Thrombosis and haemostasis

authors： Pfaffenberger S,Devcic-Kuhar B,Kastl SP,Huber K,Maurer G,Wojta J,Gottsauner-Wolf M

更新日期：2005-07-01 00:00:00

abstract：:The generation of D-dimer was studied in the course of local thrombolytic therapy of peripheral arterial occlusions with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in 7 patients. Intermittent local application of rt-PA resulted in a marked increase in D-dimer exceeding values usually seen...

journal_title：Thrombosis and haemostasis

authors： Koppensteiner R,Speiser W,Minar E,Ahmadi R,Ehringer H

更新日期：1990-10-22 00:00:00

abstract：:EPCR is a type I transmembrane protein, highly expressed on the endothelium of large vessels, that binds protein C and augments its activation. In this study, a 23bp insertion in the EPCR gene was found in 4/198 survivors of myocardial infarction and 3/194 patients with deep vein thrombosis. The EPCR gene with the ins...

journal_title：Thrombosis and haemostasis

authors： Biguzzi E,Merati G,Liaw PC,Bucciarelli P,Oganesyan N,Qu D,Gu JM,Fetiveau R,Esmon CT,Mannucci PM,Faioni EM

更新日期：2001-10-01 00:00:00

abstract：:The redistribution of platelet glycoproteins (GP) Ib, IIb and IIIa in response to stimulation with human platelet specific alloantibodies, autoantibodies and a quinidine-dependent antibody was investigated using immunofluorescence and a quantitative radioimmunoassay. The platelet GPs carrying the corresponding epitope...

journal_title：Thrombosis and haemostasis

authors： Santoso S,Kiefel V,Mueller-Eckhardt C

更新日期：1987-10-28 00:00:00

abstract：:Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis. This beneficial effect is especially apparent in patients with pneumococcal pneumonia. Earlier treatment with APC in sepsis has been associated with a better the...

journal_title：Thrombosis and haemostasis

authors： Schouten M,van 't Veer C,Roelofs JJ,Gerlitz B,Grinnell BW,Levi M,van der Poll T

更新日期：2011-12-01 00:00:00

abstract：:Myocardial infarction in the young provides a unique model for the investigation of potential interactions between atherosclerotic and prothrombotic risk factors. Because myocardial infarction reflects atherothrombotic disease, it is important to take into account factors related to atherosclerosis when examining prot...

journal_title：Thrombosis and haemostasis

authors： Siscovick DS,Schwartz SM,Rosendaal FR,Psaty BM

更新日期：1997-07-01 00:00:00

abstract：:Advanced electronic alerts (eAlerts) and computerised physician order entry (CPOE) increase adequate thromboprophylaxis orders among hospitalised medical patients. It remains unclear whether eAlerts maintain their efficacy over time, after withdrawal of continuing medical education (CME) on eAlerts and on thromboproph...

journal_title：Thrombosis and haemostasis

authors： Beeler PE,Kucher N,Blaser J

更新日期：2011-10-01 00:00:00

abstract：:In health, haemostasis and angiogenesis are tightly regulated processes, but may become deregulated in cancer. Recent evidence suggests that platelet activation may link these processes as platelets can release angiogenic factors such as vascular endothelial growth factor (VEGF). Furthermore, inflammation has also bee...

journal_title：Thrombosis and haemostasis

authors： Caine GJ,Lip GY,Stonelake PS,Ryan P,Blann AD

更新日期：2004-07-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation occurs in vascular obstructive events such as atherosclerosis and restenosis. We previously showed that Notch receptors are induced in smooth muscle cells during vascular remodeling. Our goal was to determine the mechanisms employed by Notch signaling to regulate prolif...

journal_title：Thrombosis and haemostasis

authors： Havrda MC,Johnson MJ,O'Neill CF,Liaw L

更新日期：2006-09-01 00:00:00

abstract：:The liver can be injured and its functions altered by activation of the coagulation and inflammatory processes in sepsis. The objective of the present study was to investigate the pattern of protease- activated receptors (PARs) over time in a model of acute liver injury induced by lipopolysaccharide (LPS); and whether...

journal_title：Thrombosis and haemostasis

authors： Jesmin S,Gando S,Zaedi S,Sakuraya F

更新日期：2006-12-01 00:00:00

abstract：:Early treatment of disseminated intravascular coagulation (DIC) is recommended but global coagulation tests used in authorized DIC criteria are not sensitive for diagnosis of early-phase DIC. We examined the plasma levels of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC) and D-dimer in p...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Wada H,Okamoto K,Iba T,Uchiyama T,Eguchi Y,Kawasugi K,Koga S,Mayumi T,Koike K,Gando S

更新日期：2006-02-01 00:00:00

abstract：:In this study we sought to evaluate if platelet function measured after percutaneous coronary intervention (PCI) affects the severity of myocardial infarction (MI), measured by markers of cardiac necrosis. We measured platelet function by both a point-of-care assay (PFA-100) and platelet-rich plasma aggregation by two...

journal_title：Thrombosis and haemostasis

authors： Marcucci R,Paniccia R,Antonucci E,Poli S,Gori AM,Valente S,Giglioli C,Lazzeri C,Prisco D,Abbate R,Gensini GF

更新日期：2007-10-01 00:00:00