D-dimer in local thrombolytic therapy with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in patients with peripheral arterial occlusive disease.

abstract：:Hyperhomocysteinemia is a risk factor of venous thromboembolism. The risk of recurrence in patients with hyperhomocysteinemia is unknown, and the optimal therapy for these patients after acute venous thromboembolism is uncertain. In a multicenter study, 264 patients with an objectively documented single episode of idi...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Stümpflen A,Hirschl M,Bialonczyk C,Herkner K,Stain M,Schneider B,Pabinger I,Lechner K,Kyrle PA

更新日期：1998-10-01 00:00:00

abstract：:Existing clinical scores do not perform well in predicting bleeding in elderly patients with acute venous thromboembolism (VTE). We sought to derive an easy-to-use clinical score to help physicians identify elderly patients with VTE who are at high-risk of bleeding during extended anticoagulation (>3 months). Our deri...

journal_title：Thrombosis and haemostasis

authors： Seiler E,Limacher A,Mean M,Beer HJ,Osterwalder J,Frauchiger B,Righini M,Aschwanden M,Matter CM,Banyai M,Kucher N,Staub D,Lämmle B,Rodondi N,Squizzato A,Aujesky D

更新日期：2017-08-24 00:00:00

abstract：:A four-decade clinical experience and recent evidence from randomised controlled studies definitively recognised primary prophylaxis, i.e. the regular infusion of factor concentrates started after the first haemarthrosis and/or before the age of two years, as the first-choice treatment in children with severe haemophi...

journal_title：Thrombosis and haemostasis

authors： Coppola A,Franchini M,Tagliaferri A

更新日期：2009-04-01 00:00:00

abstract：:Hot water extracts of Mo-er (1 gm by 15 ml of water), an oriental food (Auricularia auricula), inhibit strongly both human and rat platelet ADP-induced aggregation. HPLC analysis of two varieties of Mo-er, A. auricula and A. polytricha (a black tree fungus), shows that they contain adenosine (Ado), 133 and 154 microgr...

journal_title：Thrombosis and haemostasis

authors： Agarwal KC,Russo FX,Parks RE Jr

更新日期：1982-10-29 00:00:00

abstract：:We studied a murine monoclonal antibody (211 A6) to von Willebrand factor (vWF) with a view to investigating structure-relationship of plasma vWF. The specificity of this antibody has been substantiated by ELISA tests and indirect immunofluorescence. It reacts with purified vWF, normal plasma but not with plasma or pl...

journal_title：Thrombosis and haemostasis

authors： Jorieux S,de Romeuf C,Samor B,Goudemand M,Mazurier C

更新日期：1987-06-03 00:00:00

abstract：:The vitamin K-dependent carboxylation of specific glutamyl residues to gamma-carboxyglutamyl residues occurs during the endoplasmic reticulum processing of a limited number of proteins. The fate of the under-gamma-carboxylated proteins during protein processing was studied. When human hepatoma (HepG2) cells were grown...

journal_title：Thrombosis and haemostasis

authors： Wu W,Bancroft JD,Suttie JW

更新日期：1996-07-01 00:00:00

abstract：:Antithrombin readily undergoes a spontaneous transition from its active five-stranded form to a six-stranded inactive latent form. The recognition of this change in plasma has been obscured by the immediate linkage of newly formed latent antithrombin to a molecule of active antithrombin to give a dimer with an electro...

journal_title：Thrombosis and haemostasis

authors： Carrell RW,Huntington JA,Mushunje A,Zhou A

更新日期：2001-07-01 00:00:00

abstract：:Although intravital microscopy models of thrombosis in mice have contributed to dissect the mechanisms of thrombus formation and stability, they have not been well adapted to study long-term evolution of occlusive thrombi. Here, we assessed the suitability of the dorsal skinfold chamber (DSC) for the study of thrombol...

journal_title：Thrombosis and haemostasis

authors： Boulaftali Y,Lamrani L,Rouzaud MC,Loyau S,Jandrot-Perrus M,Bouton MC,Ho-Tin-Noé B

更新日期：2012-05-01 00:00:00

abstract：:The effects of G4120, a cyclic Arg-Gly-Asp (RGD) containing peptide which inhibits fibrinogen binding to the platelet receptor GPIIb/IIIa, on thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) were investigated in a combined arterial and venous thrombosis model in heparinized dogs. The arterial th...

journal_title：Thrombosis and haemostasis

authors： Lu HR,Gold HK,Wu Z,Yasuda T,Pauwels P,Rapold HJ,Napier M,Bunting S,Collen D

更新日期：1992-06-01 00:00:00

abstract：:Platelet function is dependent upon membrane receptors and their interaction with other proteins. Platelet activation appears to cause a structural change of the glycoprotein IIb/IIIa complex that exposes the fibrinogen binding site, which subsequently binds fibrinogen. Fluorescence-activated flow cytometry (FACS) is ...

journal_title：Thrombosis and haemostasis

authors： Lindahl TL,Festin R,Larsson A

更新日期：1992-08-03 00:00:00

abstract：:EPCR is a type I transmembrane protein, highly expressed on the endothelium of large vessels, that binds protein C and augments its activation. In this study, a 23bp insertion in the EPCR gene was found in 4/198 survivors of myocardial infarction and 3/194 patients with deep vein thrombosis. The EPCR gene with the ins...

journal_title：Thrombosis and haemostasis

authors： Biguzzi E,Merati G,Liaw PC,Bucciarelli P,Oganesyan N,Qu D,Gu JM,Fetiveau R,Esmon CT,Mannucci PM,Faioni EM

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND: A strong association between on-thienopyridine platelet reactivity (PR) and the risk of both thrombotic and bleeding events in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) has been demonstrated. However, no study has analyzed the relationship between on-ticagrel...

journal_title：Thrombosis and haemostasis

authors： Laine M,Panagides V,Frère C,Cuisset T,Gouarne C,Jouve B,Lemesle G,Paganelli F,Alessi MC,Mancini J,Bonello L

更新日期：2020-12-01 00:00:00

abstract：:Oxidative modification of LDL, which dysregulates the homeostasis between blood and vascular cells, and alterations of endothelial function are considered among the early events in the pathogenesis of atherosclerosis. This study was designed to evaluate the impact of progressive LDL oxidation on the thrombotic respons...

journal_title：Thrombosis and haemostasis

authors： Banfi C,Camera M,Giandomenico G,Toschi V,Arpaia M,Mussoni L,Tremoli E,Colli S

更新日期：2003-03-01 00:00:00

abstract：:The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years w...

journal_title：Thrombosis and haemostasis

authors： Baranyai Z,Krzystanek M,Jósa V,Dede K,Agoston E,Szász AM,Sinkó D,Szarvas V,Salamon F,Eklund AC,Szállási Z,Jakab F

更新日期：2014-03-03 00:00:00

abstract：:Vitamin K-dependent proteins are currently purified from pooled human plasma or produced in mammalian cell culture systems by recombinant DNA technology. Transgenic animals may provide an additional expression system for the production of these therapeutic proteins. Mice have been used to test hybrid genes which direc...

journal_title：Thrombosis and haemostasis

authors： Luboń H,Paleyanda RK

更新日期：1997-07-01 00:00:00

abstract：:Thromboelastography (TEG) has been shown to be a valuable point-of-care device for the rapid diagnosis of various bleeding disorders. However, TEG has thus far not been used for the screening for von Willebrand disease (VWD). We evaluated the performance of a modified TEG assay for the laboratory screening of VWD. Thr...

journal_title：Thrombosis and haemostasis

authors： Topf HG,Weiss D,Lischetzki G,Strasser E,Rascher W,Rauh M

更新日期：2011-06-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopaenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopaenia despite normal MK numb...

journal_title：Thrombosis and haemostasis

authors： Lorenz V,Ramsey H,Liu ZJ,Italiano J Jr,Hoffmeister K,Bihorel S,Mager D,Hu Z,Slayton WB,Kile BT,Sola-Visner M,Ferrer-Marin F

更新日期：2017-12-01 00:00:00

abstract：:Myocardial infarction in the young provides a unique model for the investigation of potential interactions between atherosclerotic and prothrombotic risk factors. Because myocardial infarction reflects atherothrombotic disease, it is important to take into account factors related to atherosclerosis when examining prot...

journal_title：Thrombosis and haemostasis

authors： Siscovick DS,Schwartz SM,Rosendaal FR,Psaty BM

更新日期：1997-07-01 00:00:00

abstract：:The German Priority Research Program "Angiogenesis" (www.angiogenese.de) hosts a biannual meeting in the Kloster Seeon in Southern Germany. The 2nd Kloster Seeon Meeting "Angiogenesis: Molecular Mechanisms and Functional Interactions" was held in September 2002. It included sessions on hypoxia, the biology of endothel...

journal_title：Thrombosis and haemostasis

authors： Augustin HG,Breier G

更新日期：2003-01-01 00:00:00

abstract：:We investigated the protective effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against two kinds of experimental disseminated intravascular coagulation (DIC) in rats. Endotoxin-induced experimental DIC was induced by a 4-h sustained infusion of endotoxin at a dose of 100 m...

journal_title：Thrombosis and haemostasis

authors： Yamazaki M,Asakura H,Aoshima K,Saito M,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Ikeda T,Matsuda T

更新日期：1994-09-01 00:00:00

abstract：:Accurate and precise measurement of plasma D-dimer levels is important in the diagnosis and management of venous thromboembolism. Considerable variability in D-dimer results obtained using different methods has, however, been reported in multicentre studies. This study explored in two separate multicentre exercises th...

journal_title：Thrombosis and haemostasis

authors： Jennings I,Woods TA,Kitchen DP,Kitchen S,Walker ID

更新日期：2007-11-01 00:00:00

abstract：:Abnormalities of Hageman factor dependent pathways have been described in a wide variety of human disease states. Congenital deficiencies of factor XII (Hageman trait) prekallikrein (Fletcher trait) and high molecular weight kininogen (Williams, Fitzgerald and Flaujeac traits) although resulting in profound in vitro c...

journal_title：Thrombosis and haemostasis

authors： Colman RW,Wong PY

更新日期：1977-12-15 00:00:00

abstract：:We studied the occurrence of myocardial infarction (MI), ischaemic stroke (IS) and pulmonary embolism (PE) before and after breast cancer hospitalisation compared with cancer-free controls. For this, women with a first breast cancer hospitalisation during 2000-2007 were selected from the PHARMO Record Linkage System, ...

journal_title：Thrombosis and haemostasis

authors： van Herk-Sukel MP,Shantakumar S,Kamphuisen PW,Penning-van Beest FJ,Herings RM

更新日期：2011-07-01 00:00:00

abstract：:Endotoxin (LPS) and interleukin-1 beta (IL-1 beta) increased in a dose-dependent manner the expression of tissue factor, an ubiquitous membrane-anchored glycoprotein that initiates blood coagulation at the surface of human umbilical vein endothelial cells (HUVEC and human peripheral blood mononuclear cells (PBMC). Ech...

journal_title：Thrombosis and haemostasis

authors： Herbert JM,Lalé A,Pereillo JM,Derocq JM,Casellas P

更新日期：1996-02-01 00:00:00

abstract：:Heparin therapy was monitored with the activated partial thromboplastin time (APTT) and with chromogenic substrate assays (factor Xa and factor IIa inhibition) in 100 plasma samples from 47 patients. Heparin concentrations were classified as being below, within or above a defined therapeutic range (TR; 0.2-0.55 units ...

journal_title：Thrombosis and haemostasis

authors： Fey MF,Lang M,Furlan M,Beck EA

更新日期：1987-10-28 00:00:00

abstract：:Bleeding and thrombotic disorders are major complications affecting patients with chronic kidney disease (CKD). Exposure of circulating platelets to uraemic toxins and contact with artificial surfaces during dialysis induce platelet abnormalities and alter the platelet proteome. We hypothesised that these changes may ...

journal_title：Thrombosis and haemostasis

authors： Plé H,Maltais M,Corduan A,Rousseau G,Madore F,Provost P

更新日期：2012-10-01 00:00:00

abstract：:Sixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 pati...

journal_title：Thrombosis and haemostasis

authors： Fiessinger JN,Aiach M,Capron L,Devanlay M,Vayssairat M,Juillet Y

更新日期：1981-06-30 00:00:00

abstract：:Abnormal antithrombin III (AT III) was found in the plasma of a 31-year-old female who suffered from recurrent thrombotic episodes. Heparin cofactor activity was 28% of normal and undetectable when measured by inhibition of thrombin and factor Xa (F.Xa), while both progressive antithrombin and antifactor Xa activities...

journal_title：Thrombosis and haemostasis

authors： Okajima K,Ueyama H,Hashimoto Y,Sasaki Y,Matsumoto K,Okabe H,Inoue M,Araki S,Takatsuki K

更新日期：1989-02-28 00:00:00

abstract：:Factor VIII inhibitors in mild haemophilia are uncommon and the management of such patients is controversial. The development of a persistently high responding F VIII inhibitor in a mild haemophiliac is reported and the behaviour of the inhibitor discussed in the context of the various therapeutic regimes employed for...

journal_title：Thrombosis and haemostasis

authors： Kesteven PJ,Holland LJ,Lawrie AS,Savidge GF

更新日期：1984-08-31 00:00:00

abstract：:Compared to second generation, the use of third generation oral contraceptives has been associated with an increased risk of venous thrombosis especially in women with the factor V Leiden mutation. To find an explanation for these risk differences we investigated the effects of desogestrel- and levonorgestrel-containi...

journal_title：Thrombosis and haemostasis

authors： Kemmeren JM,Algra A,Meijers JC,Bouma BN,Grobbee DE

更新日期：2002-02-01 00:00:00