Chemical reduction of oxidized human lymphocytes inhibits interleukin 2 production but not induction of interleukin 2 responsiveness.

abstract：:A mouse cDNA clone has been isolated that contains the complete coding region of a protein highly homologous to the delta subunit of the Torpedo acetylcholine receptor (AcChoR). The cDNA library was constructed in the vector lambda 10 from membrane-associated poly(A)+ RNA from BC3H-1 mouse cells. Surprisingly, the del...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaPolla RJ,Mayne KM,Davidson N

更新日期：1984-12-01 00:00:00

abstract：:We describe a quantum mechanics/molecular mechanics investigation of the guanidinoacetate methyltransferase catalyzed reaction, which shows that proton transfer from guanidinoacetate (GAA) to Asp-134 and methyl transfer from S-adenosyl-L-methionine (AdoMet) to GAA are concerted. By self-consistent-charge density funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang X,Bruice TC

更新日期：2006-10-31 00:00:00

abstract：:Type VI protein secretion system (T6SS) is important for bacterial competition through contact-dependent killing of competitors. T6SS delivers effectors to neighboring cells and corresponding antagonistic proteins confer immunity against effectors that are delivered by sister cells. Although T6SS has been found in mor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong TG,Ho BT,Yoder-Himes DR,Mekalanos JJ

更新日期：2013-02-12 00:00:00

abstract：:Despite the enormous theoretical attention given to the evolutionary consequences of sexual reproduction, the validity of the key assumptions on which the theory depends rarely has been evaluated. It is often argued that a reduced ability to purge deleterious mutations condemns asexual lineages to an early extinction....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Omilian AR,Cristescu ME,Dudycha JL,Lynch M

更新日期：2006-12-05 00:00:00

abstract：:Living organisms detect changes in temperature using thermosensory molecules. However, these molecules and/or their mechanisms for sensing temperature differ among organisms. To identify thermosensory molecules in plants, we investigated chloroplast positioning in response to temperature changes and identified a blue-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujii Y,Tanaka H,Konno N,Ogasawara Y,Hamashima N,Tamura S,Hasegawa S,Hayasaki Y,Okajima K,Kodama Y

更新日期：2017-08-22 00:00:00

abstract：:The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)-pyrimido[1, 2-a]purin-10(3H)-one (M1G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG).d(CGGACACC) or d(ATCGCMCGGCATG). d(C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao H,Schnetz-Boutaud NC,Weisenseel JP,Marnett LJ,Stone MP

更新日期：1999-06-08 00:00:00

abstract：:Recent studies have shown that orthotopic (transurethral) transplantation of human bladder cancer cell lines into nude mice permits tumor growth that accurately reflects their clinical malignant status in the original host. Thus, such a system allows a unique opportunity to analyze the genetic events involved in the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Theodorescu D,Cornil I,Fernandez BJ,Kerbel RS

更新日期：1990-11-01 00:00:00

abstract：:Transfer of organelle DNA into the nuclear genome has been significant in eukaryotic evolution, because it appears to be the origin of many nuclear genes. Most studies on organelle DNA transfer have been restricted to evolutionary events but experimental systems recently became available to monitor the process in real...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CY,Ayliffe MA,Timmis JN

更新日期：2004-06-29 00:00:00

abstract：:A procedure using ion exchange chromatography has been developed to detect alterations in a polysaccharide produced by Neurospora crassa. The polysaccharide, isolated from medium that has supported the growth of a culture, is highly responsive to the 3-methyl-2-benzothiazolinone hydrazone assay, indicating a high hexo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Springer WD,Srb AM

更新日期：1978-03-01 00:00:00

abstract：:Protected areas are crucial for biodiversity conservation because they provide safe havens for species threatened by land-use change and resulting habitat loss. However, protected areas are only effective when they stop habitat loss within their boundaries, and are connected via corridors to other wild areas. The effe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radeloff VC,Stewart SI,Hawbaker TJ,Gimmi U,Pidgeon AM,Flather CH,Hammer RB,Helmers DP

更新日期：2010-01-12 00:00:00

abstract：:Rapid electrical conduction in the His-Purkinje system tightly controls spatiotemporal activation of the ventricles. Although recent work has shed much light on the regulation of early specification and morphogenesis of the His-Purkinje system, less is known about how transcriptional regulation establishes impulse con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang SS,Kim KH,Rosen A,Smyth JW,Sakuma R,Delgado-Olguín P,Davis M,Chi NC,Puviindran V,Gaborit N,Sukonnik T,Wylie JN,Brand-Arzamendi K,Farman GP,Kim J,Rose RA,Marsden PA,Zhu Y,Zhou YQ,Miquerol L,Henkelman RM,Sta

更新日期：2011-08-16 00:00:00

abstract：:The β-1,3-glucan chrysolaminarin is the main storage polysaccharide of diatoms. In contrast to plants and green algae, diatoms and most other algal groups do not accumulate storage polysaccharides in their plastids. The diatom Phaeodactylum tricornutum possesses only a single gene encoding a putative β-1,3-glucan synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang W,Haferkamp I,Lepetit B,Molchanova M,Hou S,Jeblick W,Río Bártulos C,Kroth PG

更新日期：2018-05-01 00:00:00

abstract：:Most variation in behavior has a genetic basis, but the processes determining the level of diversity at behavioral loci are largely unknown for natural populations. Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lonn E,Koskela E,Mappes T,Mokkonen M,Sims AM,Watts PC

更新日期：2017-04-04 00:00:00

abstract：:Earlier work has shown that mitochondrial proteins synthesized in the cytosol are initially made as larger precursors which are then transferred into the organelles and processed to their mature size in the absence of protein synthesis. It is now demonstrated that depletion of the mitochondrial matrix ATP in intact ye...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson N,Schatz G

更新日期：1979-09-01 00:00:00

abstract：:To test the hypothesis that the nonrandom organization of the contents of interphase nuclei represents a compartmentalization of function, we examined the relative, spatial relationship of small nuclear ribonucleoproteins (snRNPs) and of DNase I hypersensitive chromatin (DHC) in rat pheochromocytoma cells. In controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park PC,De Boni U

更新日期：1996-10-15 00:00:00

abstract：:Much recent attention in the study of adaptation of organismal form has centered on developmental regulation. As such, the highly conserved respiratory machinery of eukaryotic cells might seem an unlikely target for selection supporting novel morphologies. We demonstrate that a dramatic molecular evolutionary rate inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jobson RW,Nielsen R,Laakkonen L,Wikström M,Albert VA

更新日期：2004-12-28 00:00:00

abstract：:The incidence of pediatric adrenal cortical carcinoma (ACC) in southern Brazil is 10-15 times higher than that of pediatric ACC worldwide. Because childhood ACC is associated with Li-Fraumeni syndrome, we examined the cancer history and p53 status of 36 Brazilian patients and their families. Remarkably, 35 of 36 patie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro RC,Sandrini F,Figueiredo B,Zambetti GP,Michalkiewicz E,Lafferty AR,DeLacerda L,Rabin M,Cadwell C,Sampaio G,Cat I,Stratakis CA,Sandrini R

更新日期：2001-07-31 00:00:00

abstract：:Fluorescence in situ hybridization (FISH) is a powerful tool for physical mapping in human and other mammalian species. However, application of the FISH technique has been limited in plant species, especially for mapping single- or low-copy DNA sequences, due to inconsistent signal production in plant chromosome prepa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang J,Gill BS,Wang GL,Ronald PC,Ward DC

更新日期：1995-05-09 00:00:00

abstract：:Previous studies have identified human breast tumor particles possessing many of the features characteristic of RNA tumor viruses. In addition to the expected size (600 S) and density (1.16 g/ml) these include possession of an outer membrane and an inner one surrounding a "core" containing a DNA polymerase and a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno T,Sweet RW,Dejak D,Spiegelman S

更新日期：1977-02-01 00:00:00

abstract：:Chromosome region 11p15.5 harbors unidentified genes involved in neoplasms and in the genetic disease Beckwith-Wiedemann syndrome. The genetic analysis of a 170-kb region at 11p15.5 between loci D11S601 and D11S679 resulted in the identification of six transcriptional units. Three genes, hNAP2, CDKN1C, and KVLQT1, are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwienbacher C,Sabbioni S,Campi M,Veronese A,Bernardi G,Menegatti A,Hatada I,Mukai T,Ohashi H,Barbanti-Brodano G,Croce CM,Negrini M

更新日期：1998-03-31 00:00:00

abstract：:Computers are organized into hardware and software. Using a theoretical approach to identify patterns in gene expression in a variety of species, organs, and cell types, we found that biological systems similarly are comprised of a relatively unchanging hardware-like gene pattern. Orthogonal patterns of software-like ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kravchenko-Balasha N,Levitzki A,Goldstein A,Rotter V,Gross A,Remacle F,Levine RD

更新日期：2012-03-20 00:00:00

abstract：:Lantibiotics are ribosomally synthesized, posttranslationally modified peptide antibiotics. The biosynthetic gene cluster for microbisporicin, a potent lantibiotic produced by the actinomycete Microbispora corallina containing chlorinated tryptophan and dihydroxyproline residues, was identified by genome scanning and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foulston LC,Bibb MJ

更新日期：2010-07-27 00:00:00

abstract：:In cerebellar granule neurons of neonatal rats micromolar concentrations of 7-chloro-3-methyl-3,4-dihydro-2H-1,2, 4-benzothiadiazine S,S-dioxide (IDRA-21) and cyclothiazide, two negative modulators of the spontaneous agonist-dependent rapid desensitization of alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Impagnatiello F,Oberto A,Longone P,Costa E,Guidotti A

更新日期：1997-06-24 00:00:00

abstract：:New Zealand black x New Zealand white (NZB/W) F1 mice spontaneously develop an autoimmune syndrome with notable similarities to human systemic lupus erythematosus. Female NZB/WF1 mice produce high titers of antinuclear antibodies and invariably succumb to severe glomerulonephritis by 12 months of age. Although the dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Hu Q,Madri JA,Rollins SA,Chodera A,Matis LA

更新日期：1996-08-06 00:00:00

abstract：:PTP1C, a protein-tyrosine-phosphatase (protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48) containing two src homology 2 domains, is poorly active when assayed with various protein substrates in vitro. Its activity is stimulated > 1000-fold by anionic phospholipids when myelin basic protein or mitogen-activated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Z,Shen SH,Fischer EH

更新日期：1993-05-01 00:00:00

abstract：:Recombinant immunotoxins (RITs) are chimeric proteins composed of an Fv and a protein toxin being developed for cancer treatment. The Fv brings the toxin to the cancer cell, but most of the RITs do not reach the tumor and are removed by other organs. To identify cells responsible for RIT removal, and the pathway by wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu XF,Wei J,Zhou Q,Molitoris BA,Sandoval R,Kobayashi H,Okada R,Nagaya T,Karim B,Butcher D,Pastan I

更新日期：2020-03-17 00:00:00

abstract：:Inducible cAMP early repressor (ICER) is a transcriptional repressor, which, because of alternate promoter use, is generated from the 3' region of the cAMP response modulator (Crem) gene. Its expression and nuclear occurrence are elevated by high cAMP levels in naturally occurring regulatory T cells (nTregs). Using tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaeth M,Gogishvili T,Bopp T,Klein M,Berberich-Siebelt F,Gattenloehner S,Avots A,Sparwasser T,Grebe N,Schmitt E,Hünig T,Serfling E,Bodor J

更新日期：2011-02-08 00:00:00

abstract：:There is not a single pharmaceutical that halts or even slows any neurodegenerative disease. Mounting evidence shows that prions cause many neurodegenerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best therapeutic targets. We report here that the previously identified 2-amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry DB,Lu D,Geva M,Watts JC,Bhardwaj S,Oehler A,Renslo AR,DeArmond SJ,Prusiner SB,Giles K

更新日期：2013-10-29 00:00:00

abstract：:Complexin activates Ca(2+)-triggered neurotransmitter release and regulates spontaneous release in the presynaptic terminal by cooperating with the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and the Ca(2+)-sensor synaptotagmin. The N-terminal domain of complexin is importa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai Y,Choi UB,Zhang Y,Zhao M,Pfuetzner RA,Wang AL,Diao J,Brunger AT

更新日期：2016-08-09 00:00:00

abstract：:The interference of microtubular disruptors with the uptake of amino acids and other low molecular weight substrates has been studied in Morris hepatomas, host liver, and regenerating liver. Colchicine inhibits amino acid transport (alpha-aminoisobutyric acid, L-methionine, and L-leucine) in hepatomas by 59-98% wherea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tauber R,Reutter W

更新日期：1980-09-01 00:00:00