Abstract:
:The restriction endonuclease map of the alpha and beta globin genomic region of the new human erythroleukemia line, HEL, was compared with that of normal human DNA. The HEL line, which produces mainly fetal (G gamma and A gamma) but no adult (delta and beta) globin chains, was shown to have the same pattern of DNA fragments as that of normal human DNA. This suggests that the selective expression of the gamma globin genes observed in HEL cells is not due to a major deletion or rearrangement in the epsilon-G gamma-A gamma-delta-beta gene complex. Thus, the HEL line provides a model for studying the control of globin developmental switching in cells with structurally intact globin gene regions.
journal_name
Hemoglobinjournal_title
Hemoglobinauthors
Mueller RF,Murray JC,Gelinas R,Farquhar M,Papayannopoulou Tdoi
10.3109/03630268309048653subject
Has Abstractpub_date
1983-01-01 00:00:00pages
245-56issue
3eissn
0363-0269issn
1532-432Xjournal_volume
7pub_type
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