Abstract:
:The comparative mobilities, in citrate agar electrophoresis, of 91 mutant hemoglobins are presented in relation to their molecular structure and in some cases, to their mobilities in other types of electrophoresis. More than a third of the alpha chain mutants (11 of the 27 examined) and half of the beta chain mutants (29 of 55) differ to some extent from Hb A. The helical location of the substituted residue is an important determinant of hemoglobin mobility, which is also affected by a complex interplay of other factors. When the data are combined with those of several other types of electrophoresis, they often provide presumptive (or in some cases highly specific) identifications of mutant hemoglobins and hemoglobinopathies.
journal_name
Hemoglobinjournal_title
Hemoglobinauthors
Schneider RG,Hightower Bdoi
10.3109/03630267709027861subject
Has Abstractpub_date
1977-01-01 00:00:00pages
427-44issue
5eissn
0363-0269issn
1532-432Xjournal_volume
1pub_type
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