Abstract:
:Chronic blood transfusions are necessary for patients with hereditary anemia such as thalassemia, and for patients with myelodysplastic syndrome (MDS) who become anemic and transfusion-dependent. A common consequence of chronic transfusion is iron accumulation that can lead to organ damage. While there is general agreement regarding the value of iron chelation therapy to reduce the detrimental effects of iron overload in thalassemia major, the same is not true for MDS. The malignant nature of the disease and the relatively high cost of iron chelation therapy make cost-effectiveness an issue of great concern. Furthermore, the positive assessment of a drug's cost-effectiveness in one country does not necessarily justify its use in another country. More prospective studies are needed to identify the best iron chelator for patients with MDS as well as to identify those patients who will benefit most from iron chelation therapy.
journal_name
Hemoglobinjournal_title
Hemoglobinauthors
Yeh SP,Yang YS,Yao CY,Peng CTdoi
10.3109/03630260903212654subject
Has Abstractpub_date
2009-01-01 00:00:00pages
339-45issue
5eissn
0363-0269issn
1532-432Xpii
10.3109/03630260903212654journal_volume
33pub_type
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