Abstract:
:Hb Uxbridge [beta 20(B2)Val-->Gly] was found in an English family during a neonatal hemoglobinopathy screening program. In both the child and the parent carrying this hemoglobin variant, the red cell parameters were normal. By isoelectrofocusing Hb Uxbridge appeared to have an isoelectric point slightly higher than Hb A but was silent on cellulose acetate and acid gel electrophoresis. Structural modifications affecting position beta 20(B2) have been demonstrated to be responsible for a high oxygen affinity and polycythemia in Hb Olympia (Val-->Met) and Hb Trölhattan (Val-->Glu). In the case of Hb Uxbridge, despite an alteration of the same site, the oxygen binding parameters of the patient's hemolysate showed only a mild (ca. 20%) increase in oxygen affinity.
journal_name
Hemoglobinjournal_title
Hemoglobinauthors
Wajcman H,Promé D,Kister J,Davies SC,Galactéros F,Henthorn JSdoi
10.3109/03630269609005838subject
Has Abstractpub_date
1996-11-01 00:00:00pages
339-50issue
4eissn
0363-0269issn
1532-432Xjournal_volume
20pub_type
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